CAS: 38778-30-2; (2S,3R,5S,9R,10R,11R,13R,14S,17S)-17-[(2R,3R)-2,3-Dihydroxy-6-Methylheptan-2-Yl]-2,3,5,11,14-Pentahydroxy-10,13-Dimethyl-1,2,3,4,9,11,12,15,16,17-Decahydrocyclopenta[a]Phenanthren-6-One

专利信息

专利号:WO-0031134-A9
优先权日:1998-11-20
标题:Regulation of hair follicle morphogenesis based on beta-catenin
发明人：GAT URI; DASGUPTA RAMANUJ; DEGENSTEIN LINDA; FUCHS ELAINE
权利人:ARCH DEV CORP; GAT URI; DASGUPTA RAMANUJ; DEGENSTEIN LINDA; FUCHS ELAINE
摘要:The present invention provides a method for inducing hair growth by providing beta-catenin activity to a skin cell. This may be achieved by providing a beta-catenin polypeptide, providing a beta-catenin agonist, providing a polynucleotide encoding a beta-catenin polypeptide, enhancing the de novo synthesis of beta-catenin, increasing the stability or decreasing the degradation of beta-catenin polypeptides.

专利号:US-7439027-B2
优先权日:1995-01-13
标题 :Method for modulating process mediated by farnesoid activated receptors
发明人：EVANS RONALD M; FORMAN BARRY M; WEINBERGER CARY A
权利人:SALK INST FOR BIOLOGICAL STUDI; LIGAND PHARM INC; USA
摘要:Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway can be modulated by the use of key metabolic intermediates (or analogs and/or derivatives thereof) as transcriptional regulatory signals.

专利号:US-2004039197-A1
优先权日:2001-09-03
标题:Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals
发明人：WEINBERGER HEINZ; BECKERS THOMAS; SCHMIDT MATHIAS; BAASNER SILKE; NICKEL BERND
摘要:The invention relates to novel, substituted, fused indole and heteroindole derivatives of the general formula I n n n their tautomers, stereoisomers, mixtures and pharmaceutically acceptable salts, their synthesis and their use as pharmaceuticals, especially as anti-tumor agents, for mammals, especially for man.

专利号:US-9700589-B2
优先权日:2015-02-03
标题:Compositions and methods for improved muscle metabolism
发明人：BILY ANTOINE CHARLES; MEYER MARJOLAINE; CHEVALIER KARL; Laurençon Lise; FEUILLERE NICOLAS; ROLLER MARC; BIRTIC SIMONA
权利人:NATUREX SA
摘要:A composition for improving muscle metabolism in a subject and methods for manufacturing and using same. Embodiments include compositions having an extract of Rhaponticum and an extract of Rhodiola . An extract of Rhaponticum may include amounts of ecdysterones including 20-hydroxyecdysone. An extract of Rhodiola my include salidrosides and rosavins, including rosavin. Suitable ingestion dosages of the composition may be operable to increase protein synthesis and reduce protein proteolysis in a subject.

专利号:WO-2004046348-A1
优先权日:2002-11-17
标题:Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
发明人：OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
权利人:UNIV RAMOT; OFFEN DANIEL; MELAMED ELDAD; LEVY YOSEF
摘要:A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.

专利号:US-2013236964-A1
优先权日:2002-11-17
标 题:Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
发明人：MELAMED ELDAD; OFFEN DANIEL; LEVY YOSEF; GREEN PNINA
权利人:UNIV RAMOT
摘要:A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter synthesis thereby treating the neurodegenerative disorder.