CAS: 36817-69-3; (R)-2-(6-Amino-9H-Purin-9-yl)Propan-1-Ol

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methanol (R)-9-(1-methyl-2-hydroxyethyl)-6-chloropurine

📜甲醇,(R)-9-(1-Methyl-2-Hydroxyethyl)-6-Chloropurine置于氨体系中,化学反应 48.0H,以86%的收率获得替诺福韦杂质b
参考文献:Synthesis Of Acyclic Nucleoside And Nucleotide Analogues From Amino Acids: A Convenient Approach To A Pmea-pmpa Hybrid
标题:Synthesis Of Acyclic Nucleoside And Nucleotide Analogues From Amino Acids: A Convenient Approach To A Pmea-pmpa Hybrid
摘要:Nonracemic Amino Alcohols Derived From Common Amino Acids Have Been Used To Assemble Acyclic Nucleoside And Nucleotide Analogues With Control Of Absolute Stereochemistry. Both (R)-And (S)-2-Amino-1-Propanol,Readily Available From D-Or L-Alanine,Were Used To Prepare The Nucleoside Analogues (R)-And (S)-9-[1-Methyl-2-Hydroxyethyl]Adenine,And Then The Nucleotide Analogues (R)-And (S)-9-[1-Methyl-2-Phosphonomethoxyethyl] Adenine. In A Similar Fashion,The Cbz Derivative Of L-Threonine Was Used To Prepare First (1R,2R)-9-[1-Hydroxymethyl-2-Hydroxypropyl]Adenine,And Then The Bis Phosphonomethoxy Derivative. The Bis Phosphonate Derived From Threonine Represents A Unique Structural Hybrid Of Pmea And Pmpa,Both Of Which Have Well Established Antiviral Activity. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4020(00)00422-1