在 硫酸,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 甲醇,水 作为反应溶剂,化学反应 1.0H,反应生成 6-溴-2-萘甲酸甲酯
参考文献:Discovery And Crystallography Of Bicyclic Arylaminoazines As Potent Inhibitors Of Hiv-1 Reverse Transcriptase
标题:Discovery And Crystallography Of Bicyclic Arylaminoazines As Potent Inhibitors Of Hiv-1 Reverse Transcriptase
摘要:Non-Nucleoside Inhibitors Of Hiv-1 Reverse Transcriptase (Hiv-Rt) Are Reported That Incorporate A 7-In-Dolizinylamino Or 2-Naphthylamino Substituent On A Pyrimidine Or 1,3,5-Triazine Core. The Most Potent Compounds Show Below 10 Nanomolar Activity Towards Wild-Type Hiv-1 And Variants Bearing Tyr181Cys And Lys103Asn/tyr181Cys Resistance Mutations. The Compounds Also Feature Good Aqueous Solubility. Crystal Structures For Two Complexes Enhance The Analysis Of The Structure-Activity Data. (C) 2015 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2015.06.074