CAS: 33420-52-9; 2,2-Difluoropropan-1-Ol

相似化合物

28781-85-3 373-96-6 38650-84-9

上下游产品

3-chloro-2-fluoro-1-propanol 2,2-difluoropropyl fluorosulfite Benzoic acid 2,2-difluoropropyl ester methyl 2,2-difluoropropionate 2,2-difluoropropyl 4-methylbenzenesulfonate 2,2-difluoropropyl 4-nitrobenzenesulfonate 9H8BrF2NO3C9H8BrF2NO3

2,2-二氟丙酸甲酯置于ru-Macho,氢气,Sodium Methylate体系中,用 甲醇 用作溶剂,40.0 °C,1.01 Mpa 条件下,反应 6.0H,反应生成2,2-二氟丙醇
参考文献:α-氟化酯与双功能钳型钌 (II) 催化剂的实际选择性加氢生成氟化醇或氟半缩醛
标题:α-氟化酯与双功能钳型钌 (II) 催化剂的实际选择性加氢生成氟化醇或氟半缩醛
摘要:用钳型双功能催化剂 Ruhcl(Co)(Dpa) 1A,反式-Ruh2(Co)(Dpa) 1B 和反式-Rucl2(Co)(Dpa) 1C 在温和条件下选择性氢化氟化酯迅速进行,得到相应的氟化醇或半缩醛,收率非常好至极好.在优化条件下,手性(R)-2-氟丙酸酯的加氢反应顺利进行,得到相应的手性醇,Ee值没有出现严重下降.
Doi:10.1021/ja403852E

专利信息

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-4255594-A
优先权日:1979-09-18
标题 :Hydrogenation of halogen-containing carboxylic anhydrides
发明人：NOVOTNY MIROSLAV
权利人:ALLIED CHEM
摘要:A process is described for the heterogeneous hydrogenation of haloalkyl, halocycloalkyl or haloaryl carboxylic anhydrides to the corresponding primary alcohols. In the haloalkyl or halocycloalkyl carboxylic anhydrides at least one halogen is in the alpha-position relative to the carboxylic anhydride grouping. The hydrogenation can be carried out in the liquid or vapor phase in the presence of a supported or unsupported catalyst comprising a member of the group consisting of rhodium, iridium, metal oxides thereof, or mixtures thereof. In the liquid phase, the hydrogenation can be carried out batchwise under mild conditions of temperature and pressure, preferably at about 50°-150° C. and about 5-15 atmospheres, in an atmosphere containing hydrogen gas. A preferred embodiment is the hydrogenation of trifluoroacetic anhydride in the liquid phase to 2,2,2-trifluoroethanol, said alcohol being useful as an intermediate in the synthesis of the anesthetic, isoflurane, CF 3 CHClOCHF 2 .

专利号:WO-8911470-A1
优先权日:1988-05-27
标题 :Dihalogeno-3,3 fluoro-2 propenols-1, preparation method and utilization for the synthesis of fluoro-2 acrylic and dihalogeno-3,3 fluoro-2 acrylic acids and their derivatives
发明人：WAKSELMAN CLAUDE; NGUYEN THOAI; MOLINES HUGUETTE
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to dihalogeno-3,3 fluoro-2 propenol-1 having the formula X?1X?2C=CF-CH2?OH (I), wherein X?1 and X?2, which may be identical or different, represent a fluorine, a chlorine or a bromine atom providing that X?1 and X?2 do not represent both a chlorine atom. These compounds may be prepared by reaction of an alcohol having the formula HCH?1X?2-CFX?3-CH2?OH (II), X?1 and X?2 have the meaning given hereabove and X?3 is a fluorine, chlorine or bromine atom, similar to or different from X?1 and/or X?2, with an organolithian compound. They may be used to prepare halides of the fluoro-2 acrylic acid and of the dihalogeno-3,3 fluoro-2 acrylic acids or their esters.

专利号:US-10919921-B2
优先权日:2016-05-06
标题:P-chiral phosphine ligands and use thereof for asymmetric synthesis
发明人：BOERNER ARMIN; HOLZ JENS; RUMPEL KATHARINA
权利人:BASF SE
摘要:The present invention relates to chiral compounds with two optically active phosphorus atoms, chiral transition metal catalysts which comprise these compounds as ligands, a process for preparing the P-chiral compounds and processes for asymmetric synthesis using the chiral transition metal catalysts. The present invention specifically relates to a process for preparing an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of an optically active transition metal catalyst according to the invention. Yet more specifically, the present invention relates to a process for the asymmetric hydrogenation of citral, and also a process for preparing optically active menthol.

专利号:US-7375058-B2
优先权日:2001-09-14
标 题:Herbicidal mixtures based on 3-phenyluracils
发明人：ZAGAR CYRILL; SIEVERNICH BERND; QUAKENBUSH LAURA; EVANS RICHARD R; LANDES MAX; NEWSOM LARRY J; ORTLIP CHARLES L; WITSCHEL MATTHIAS; LANDES ANDREAS
权利人:BASF AG
摘要:Herbidically active compositions, comprising: A) at least one phenyluracil compound of the formula (I); in which the variables R 1 -R 7 are as defined in the claims, and/or at least one of its agriculturally acceptable salts; and at least one further active compound, selected from B) herbicides of classes b1) to b15): b1) lipid biosynthesis inhibitors; b2) acetolactate synthase inhibitors (ALS inhibitors); b3) photosynthesis inhibitors; b4) protoporphyrinogen-IX oxidase inhibitors; b5) bleacher herbicides; b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors); b7) glutamine synthetase inhibitors; b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors); b9) mitose inhibitors; b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors); b11) cellulose biosynthesis inhibitors; b12) decoupler herbicides; b13) auxin herbicides; b14) auxin transport inhibitors; b15) other herbicides selected from the group consisting of benzoylprop, flamprop, flamprop-M, bromobutide, chlorflurenol, cinmethylin, methyldymron, etobenzanid, fosamine, metam, pyributicarb, oxaziclomefone, dazomet, triaziflam and methyl bromide; and safeners selected from: benoxacor, cloquintocet, cyometrinil, dichlormid, dicyclonon, dietholate, fenchlorazole, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen, mefenpyr, mephenate, naplithalic anhydride, 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane and oxabetrinil, the agriculturally acceptable salts of the active compounds B and C and the agriculturally acceptable derivatives of the active compounds B and C, provided they have a carboxyl group

专利号:WO-2012011864-A1
优先权日:2010-07-19
标题 :Bicyclic compounds and process for preparation
发明人：GIDLOEF RITHA; JOHANSSON MARTIN; STERNER OLOV
权利人:PARTNERS FOER UTVECKLINGSINVESTERINGAR INOM LIFE SCIENCES P U L S AB; GIDLOEF RITHA; JOHANSSON MARTIN; STERNER OLOV
摘要:The present invention discloses a novel process for preparation of bicyclic compounds, being useful as late intermediates in the synthesis of galiellalactone or related tricyclic compounds with biological activity, from acetylenic intermediates.