CAS: 2439-85-2; 2-Bromoisoindoline-1,3-Dione

该化合物是一种该化合物是一种稳定,晶状的固体,与液体溴化剂相比,便于处理和储存.试剂在药物和精细化学合成中特别宝贵,在这些化学合成中,温和的条件和再生选择性至关重要.其二氯化物副产品很容易分离,简化净化.NBP与各种溶剂和功能组的兼容性进一步增强了其在复杂的合成路径上的效用.

结构式图片

相似化合物

3481-09-2 6941-75-9 550-44-7

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上下游产品

CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号86451-26-5 Phenyliodine(II... | CAS号7732-18-5 水 | CAS号67-66-3 氯仿 | CAS号7726-95-6 溴素 | CAS号33081-78-6 邻苯二甲酰亚胺钠盐 | CAS号100-09-4 对甲氧基苯甲酸 | CAS号17796-82-6 防焦剂CTP | CAS号92-92-2 4-苯基苯甲酸 | CAS号100-39-0 溴化苄 | CAS号520-03-6 N-苯基邻苯二甲酰亚胺 | CAS号118-92-3 邻氨基苯甲酸 | CAS号574-98-1 N-(2-溴乙基)邻苯二甲酰亚胺 | CAS号5680-61-5 邻苯二甲酰亚胺基丙二酸二乙酯 | CAS号615-57-6 2,4-二溴苯胺

合成工艺路线路线简述

  • 合成目标产物 N-Bromophthalimide 主要起始原料 Potassium Phthalimide
  • (文献来源)合成步骤主要原料 Potassium Phthalimide
📜Potassium Phtalimide置于溴体系中,用 四氯化碳,乙腈 用作溶剂,化学反应 24.0H,反应生成N-溴酞亚胺
参考文献:Phenyliodine(III) Bis[phthalimidate]: A Novel Polyvalent Iodine Compound
标题:Phenyliodine(III) Bis[phthalimidate]: A Novel Polyvalent Iodine Compound
摘要:
Doi:10.1055/s-1983-30282

海关参考信息

专利信息


专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-11512062-B2
优先权日:2018-10-15
标 题:Process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them
发明人:BEAUREGARD LOUIS-PHILIPPE; BERTRAND MARTIAL; GIGUERE PASCALL; HARDOUIN CHRISTOPHE; SCHIAVI BRUNO
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:WO-2024018354-A1
优先权日:2022-07-18
标题 :A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof
发明人:MAL SANJIB; SARKAR PARANTAP; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER GUENTHER MARIA
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).

专利号:WO-2017021270-A1
优先权日:2015-08-03
标 题 :Process for the synthesis of ravidasvir
发明人:CASTALDI GRAZIANO; BARUTO ALESSANDRO; OLDANI ERMINIO; GABOARDI MAURO
权利人:HC-PHARMA AG
摘要:A process for the synthesis of ravidasvir and intermediates useful in the preparation thereof are disclosed.

专利号:US-11365211-B2
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides
发明人:ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY
权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH
摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人:STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: A El-Brashy, Et Al. Titrimetric Determination Of Acetylenic Hyponotics Using Organic Brominating Agents. Pharm Weekbl Sci. 1988 Apr 22;10(2):90-2.
[参考文献]: A M El-Brashy, Et Al. Colorimetric And Titrimetric Assay Of Isoniazid. J Pharm Biomed Anal. 1992 Jun;10(6):421-6.
[参考文献]: Feng Chen, Et Al. C2-Symmetric Cyclic Selenium-Catalyzed Enantioselective Bromoaminocyclization. J Am Chem Soc. 2013 Jan 30;135(4):1232-5.
[参考文献]: K G Kumar, Et Al. Titrimetric Methods For The Determination Of Some Sulpha Drugs Using N-Bromophthalimide And N-Bromosaccharin. Analyst. 1988 Sep;113(9):1369-72.
[参考文献]: Keiji Mori, Et Al. Enantioselective Synthesis Of Multisubstituted Biaryl Skeleton By Chiral Phosphoric Acid Catalyzed Desymmetrization/kinetic Resolution Sequence. J Am Chem Soc. 2013 Mar 13;135(10):3964-70.

合成参考文献


摘要:Huy, P.; Czekelius, C., Science of Synthesis Knowledge Updates, (2019) 2, 143.
摘要:Dagousset, G.; Masson, G., Science of Synthesis Knowledge Updates, (2015) 1, 450.
摘要:Dagousset, G.; Masson, G., Science of Synthesis Knowledge Updates, (2015) 1, 432.
摘要:Duschmalé, J.; Arakawa, Y.; Wennemers, H., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 781.
摘要:Andries-Ulmer, A.; Gulder, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 409.
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