CAS: 21901-18-8; 4-Methyl-3-Nitropyridin-2(1H)-One

相似化合物

22934-13-0 160590-36-3 228410-90-0

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CAS号6635-86-5 2-氨基-4-甲基-3-硝基吡啶 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号393-53-3 3-氟吡啶-4-羧酸 | CAS号59290-82-3 3-硝基异烟酸 | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号5832-44-0 4-甲基-3-硝基吡啶 | CAS号399-88-2 3-氟-4-甲基吡啶 | CAS号21203-74-7 4-甲基-3-硝基吡啶-2-甲醛 | CAS号343-72-6 3-氟-异烟酸乙酯 | CAS号33252-54-9 3-氨基-2-羟基-4-甲基吡啶 | CAS号353281-15-9 2-氯-3-硝基-4-吡啶羧酸 | CAS号228410-90-0 5-溴-4-甲基-3-硝基-2...

2-氨基-3-硝基-4-甲基吡啶置于硫酸,Sodium Nitrite体系中,用 水 用作溶剂,以90 %的收率获得2-羟基-3-硝基-4-甲基吡啶
参考文献:新型3,7-二芳基取代的6-氮杂吲哚的合成,细胞毒活性评价及机理研究
标题:新型3,7-二芳基取代的6-氮杂吲哚的合成,细胞毒活性评价及机理研究
摘要:已经设计和合成了许多新的二取代 6-氮杂吲哚,其对类似的抗增殖命中化合物进行了关键的结构修饰.使用 2-氨基-3-硝基-4-甲基吡啶进行合成,将其适当修饰并转化为 7-氯-3-碘-6-氮杂吲哚,并且该中心支架用于连续的铃木型偶联,从而产生在目标化合物中.针对四种人类癌细胞系以及正常人类成纤维细胞株进行细胞毒性活性的评估.某些化合物具有很强的抗癌活性而不影响正常细胞.在癌细胞的亚细胞毒性浓度下,这些化合物通过将细胞阻滞在细胞周期的g 2 /m 期而表现出抗增殖作用,这可能与观测到的 Mek1-Erk1/2 磷酸化水平的降低有关途径和/或 P53-P21 Waf1轴的激活.
Doi:10.1016/j.Ejmech.2023.115804

专利信息

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5869676-A
优先权日:1997-05-15
标题:Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP
发明人：NIU CHUANSHENG; LI JUN; LI XIUYAN; DOYLE TERRENCE W; CHEN SHU-HUI
权利人:VION PHARMACEUTICALS INC
摘要:The present invention relates to improved, efficient chemical syntheses of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP).

专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:RU-2198875-C2
优先权日:1997-05-15
标 题:Methods of synthesis of pyridine-2-carboxaldehyde thiosemicarbazones and intermediate pyridine-2-carboxaldehydes

专利号:US-5596001-A
优先权日:1993-10-25
标题 :4-aryl-3-(heteroarylureido)quinoline derivatves
发明人：HAMANAKA ERNEST S
权利人:PFIZER
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.

专利号:EP-0984932-A4
优先权日:1997-05-15
标题:METHOD FOR THE SYNTHESIS OF THE RIBONUCLEOTIDE REDUCTASE INHIBITORS 3-AP AND 3-AMP