CAS: 21888-98-2; (S)-1'-Benzyl-3-Phenyl-[3,4'-Bipiperidine]-2,6-Dione
该化合物是一种化学化合物,被归类为抗胆碱基剂,主要用于治疗与过度流出有关的各种病症,并用作某些胃肠道紊乱管理的一种辅助物;它的作用是阻断肌肉受体的乙酰胆碱,导致分泌减少和肌肉肌肉肌肉萎缩;Dexetimide的特征是能够跨越血脑屏障,这可能会助长其...
- 英文名称(S)-1'-Benzyl-3-Phenyl-[3,4'-Bipiperidine]-2,6-Dione
- 中文名称S-(+)-右苄替米特
- IUPAC名称(S)-1'-benzyl-3-phenyl-[3,4'-bipiperidine]-2,6-dione
- 其它别名(3S)-3-(1-Benzylpiperidin-4-yl)-3-Phenylpiperidine-2,6-Dione; (S)-(+)-Dexetimide; Dexetimide [mart.]; Dexetimide [who-Dd]; [3,4'-Bipiperidine]-2,6-Dione, 3-Phenyl-1'-(Phenylmethyl)-, (3S)-; Dexetimide [usan:Inn:Ban]; Be
- CAS编号21888-98-2
- MFCD编号:MFCD00242706
- FDA UNII编号:43477QYX3D
- 分子式:C23H26N2O2分子量:362.47
- 产品CID: 1137492
- 同类组份化合物CAS21888-96-0 (HCl)21888-98-2 (free base)
- 产品分类原料药 → 神经系统用药 → 拟胆碱药
物理性质
MSDS等安全信息
上下游产品
Benzetimide(S)-(+)-3-Phenyl-3-(4-piperidinyl)-2,6-piperidinedione methyl>-4-piperidinyl>-2,6-piperidinedione(S)-3-Phenyl-3-1-4-(trimethylsilyl)phenylmethyl-4-piperidinyl-2,6-piperidinedione -4-piperidinyl>-2,6-piperidinedione hydr°Chloride(S)-3-Phenyl-3-1-(4-iodophenyl)methyl-4-piperidinyl-2,6-piperidinedione hydr°Chloride合成工艺路线路线简述
- 合成目标产物 Benzetimide 主要起始原料 3-(1-Benzyl-4-Piperidyl)-3-Phenyl-Piperidine-2,6-Dione
- (文献来源)合成步骤主要原料 3-(1-Benzyl-4-Piperidyl)-3-Phenyl-Piperidine-2,6-Dione
📜3-苯基-1'-(苯基甲基)-[3,4'-联哌啶]-2,6-二酮 以 乙醇,正庚烷 用作溶剂,化学反应生成右苄替米特,Levetimide
参考文献:Wo2007/90826
标题:Wo2007/90826
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2912110000-甲醛
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专利信息
专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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主要参考文献
1: Bakker G, Vingerhoets WA, van Wieringen JP, de Bruin K, Eersels J, de Jong J, Chahid Y, Rutten BP, DuBois S, Watson M, Mogg AJ, Xiao H, Crabtree M, Collier DA, Felder CC, Barth VN, Broad LM, Bloemen OJ, van Amelsvoort TA, Booij J. 123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo. J Nucl Med. 2015 Feb;56(2):317-22. doi: 10.2967/jnumed.114.147488. Epub 2015 Jan 15. doi: 10.1016/j.nucmedbio.2013.10.003. Epub 2013 Oct 18. doi: 10.1016/j.cardfail.2014.06.001. Epub 2014 Jun 18. Chinese. German. Czech.
合成参考文献
参考文献:10.1016/0969-8051(95)02045-4
摘要:Kassiou M, Mardon K, Katsifis AG, Najdovski L, Dikic B, Mattner F, Lambrecht RM, Hicks RJ, Eu P, Loc'h C. Radiosynthesis of [123I]N-methyl-4-iododexetimide and [123I]N-methyl-4-iodolevetimide: In vitro and in vivo characterisation of binding to muscarinic receptors in the rat heart. Nuclear Medicine and Biology. 1996 Feb;23(2):147–53. doi: 10.1016/0969-8051(95)02045-4.
参考文献:10.1016/0731-7085(96)01722-0
摘要:Sˇmisterova´ J, Ensing K, de Zeeuw RA. Effect of purification followed by solubilization of receptor material on quantitative receptor assays for anticholinergic drugs. Journal of Pharmaceutical and Biomedical Analysis. 1996 Aug;14(11):1425–33. doi: 10.1016/0731-7085(96)01722-0.
参考文献:10.1007/s002590050445
摘要:Mardon K, Kassiou M, Katsifis A, Najdovski L. A study of myocardial muscarinic receptors in streptozotocin-induced diabetic rats using iodine-123 N -methyl-4-iododexetimide. European Journal of Nuclear Medicine and Molecular Imaging. 1999 Jun 23;26(7):743–9. doi: 10.1007/s002590050445.
参考文献:10.1016/0014-2999(92)90692-w
摘要:Varastet M, Brouillet E, Chavoix C, Prenant C, Crouzel C, Stulzaft O, Bottlaender M, Cayla J, Mazière B, Mazière M. In vivo visualization of central muscarinic receptors using [11C]quinuclidinyl benzilate and positron emission tomography in baboons. Eur J Pharmacol. 1992 Mar 24;213(2):275–84. doi: 10.1016/0014-2999(92)90692-w.
参考文献:10.1016/0006-8993(86)90414-2
摘要:Consolo S, Wang JX, Fiorentini F, Vezzani A, Ladinsky H. In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats. Brain Res. 1986 May 28;374(2):212–8. doi: 10.1016/0006-8993(86)90414-2.
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