CAS: 166281-37-4; 2-Bromo-4,5-Difluorophenol

该化合物是一种有机化合物,其特征是存在一个溴原子和两个与苯球环相连的氟原子,该化合物的特征是氢氧(-OH),有助于将其分类为苯酚;溴和氟素替代成分影响其反应性和物理特性,如溶性点和沸点;通常,2-溴-4-5-二氟酚等化合物由于电阴性卤素原子而表现出中度极性,这可以增强氢联结能力;该化合物因其独特的电子特性,可用于各种化学合成,特别是制药或农用化学品开发;此外,卤素的存在可能会影响化合物的稳定性和再活动性,使其成为与卤化有机化合物有关的研究的焦点;在处理时,应参考安全数据,因为卤化化合物可能对健康构成风险.

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186590-23-8 496-69-5 147460-41-1

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上下游产品

3,4-difluorophenol 2-(1-cyclopentenyl)-4,5-difluorophenol 1-bromo-2-(difluoromethoxy)-4,5-difluorobenzene 7-bromo-4,5-difluoro-1-benzofuran

合成工艺路线路线简述

    📜3,4-二氟苯酚置于溴,溶剂黄146体系中,化学反应 0.5H,反应生成2-溴-4,5-二氟苯酚
    参考文献:铜催化苯甲酰胺与芳烃的选择性邻位-C-h / N-h环合反应:菲啶酮类生物碱的合成
    标题:铜催化苯甲酰胺与芳烃的选择性邻位-C-h / N-h环合反应:菲啶酮类生物碱的合成
    摘要:已经开发出一种有效且方便的铜催化方法,以实现直接邻位-C-H / Nh环化反应,以合成具有芳烃的菲啶酮.该方法突显了一种新兴的策略,可将惰性c-h键转变为有机合成中的多功能官能团,并为有效合成菲啶酮类生物碱提供了新途径.
    Doi:10.1021/acs.Orglett.7B00442

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:EP-2644618-A1
    优先权日:2007-02-09
    标题:tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators

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    主要参考文献

    参考标题:Synthesis Of O-Aryloxy Triarylsulfonium Salts Via Aryne Insertion Into Diaryl Sulfoxides
    作者:Xiaojin Li,Yan Sun,Xin Huang,Lei Zhang,Lichun Kong,Bo Peng |发布日期:2017.2.17
    摘要:The Aryne Insertion Into "S═o" Bond Has Been Validated Recently. This Technology Is Elusively Applied To The Synthesis Of Thioethers. In Contrast To The Reported Cases, The Reaction Described Furnished O-Aryloxy Triarylsulfonium Salts, In Lieu Of Thioethers, In Good To Excellent Yields. The Reaction Is Also Featured By Its Exquisite Regioselectivity, Broad Substrate Scope, And Mild Conditions (25 °C)

    合成参考文献

    参考DOI号:10.1021/acs.orglett.7b00442
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