CAS: 163521-20-8; Ethyl 5-Piperazin-1-Ylbenzofuran-2-Carboxylate

相似化合物

1422956-31-7 765935-67-9 183288-47-3

上下游产品

5-(哌嗪-1-基)苯并呋喃-2-羧酸 5-(Piperazin-1-yl)Benzofuran-2-Carboxylic Acid
5-氨基苯并呋喃甲酸乙酯 Ethyl 5-Amino-1-Benzofuran-2-Carboxylate 174775-48-5
5-硝基苯并呋喃-2-羧酸乙酯 Ethyl 5-Nitrobenzo[d]Furan-2-Carboxylate 69604-00-8
5-硝基苯并呋喃-2-甲酸 5-Nitrobenzofuran-2-Carboxylic Acid 10242-12-3

1-对羟基苯基哌嗪置于potassium Carbonate,N,N-二异丙基乙胺,Sodium Iodide,Magnesium Chloride体系中,用 N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 12.0H,反应生成维拉佐酮中间体5-(哌嗪-1-基)苯并呋喃-2-甲酸乙酯
参考文献:维拉唑酮中间体及其盐的合成方法
标题:维拉唑酮中间体及其盐的合成方法
摘要:本发明涉及一种维拉唑酮中间体5-(4-[4-(5-氰基-3-吲哚基)-丁基]-1-哌嗪基)苯并呋喃-2-羧酸乙酯及其盐的合成方法,属于药物合成技术领域.所述的合成方法包括以下步骤:氮气保护下,将3-(4-氯丁基)-5-氰基吲哚与催化剂溶于无水溶剂,加热回流搅拌后加入5-(哌嗪-1-基)苯并呋喃-2-羧酸乙酯和碱,在80~110oc的条件下反应4~6小时,室温搅拌下缓慢倒入碱性水溶液至析出固体,后处理得5-(4-[4-(5-氰基-3-吲哚基)-丁基]-1-哌嗪基)苯并呋喃-2-羧酸乙酯.该合成方法的生产成本低,绿色环保,操作安全性高,产物的收率和纯度高,质量好,适合大规模工业化生产.

专利信息

专利号:US-2014275542-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor
发明人：TADDEI MAURIZIO; GIANNOTTI LUCA; ATTOLINO EMANUELE; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.

专利号:US-5977112-A
优先权日:1995-04-20
标 题:Process of making substituted benzofurans
发明人：BATHE ANDREAS; HELFERT BERND; BOTTCHER HENNING; SCHUSTER KURT
权利人:MERCK PATENT GMBH
摘要:Benzofurans of the formula I ##STR1## and their salts in which R 1 , R 2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

专利号:EP-2778165-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor

专利号:RU-2132848-C1
优先权日:1993-09-30
标题:Derivatives of piperidine and piperazine, method of their synthesis, pharmaceutical compositions containing on said and method of their preparing

专利号:CN-107674052-A
优先权日:2017-08-29
标 题 :Synthesis method of vilazodone intermediate 5-(1-piperazinyl)-2-benzofuran-2-carboxylate ethyl ester

专利号:CN-107540646-B
优先权日:2017-08-29
标 题:Synthesis method of vilazodone intermediate