CAS: 1121-86-4; 1-Fluoro-3-Iodobenzene

相似化合物

2265-91-0 352-34-1 147808-02-4

上下游产品

CAS号372-19-0 3-氟苯胺 | CAS号7217-41-6 (3-fluorophenyl... | CAS号462-06-6 氟苯 | CAS号108-95-2 苯酚 | CAS号352-70-5 3-氟甲苯 | CAS号455-38-9 间氟苯甲酸 | CAS号455-37-8 间氟苯甲酰胺 | CAS号455-36-7 间氟苯乙酮 | CAS号47230-38-6 4,4'-联苯二甲酸二乙酯 | CAS号396-64-5 3,3'-二氟联苯 | CAS号462-06-6 氟苯 | CAS号1496-00-0 1-Fluoro-3-benz... | CAS号146137-94-2 6-碘-苯并[b]噻吩-2-羧酸甲酯 | CAS号403-54-3 3-氟苯甲腈

3-氟苯基硼酸置于碘,Potassium Carbonate体系中,用 甲苯 用作溶剂,70.0 °C,100.0 Kpa 条件下,反应 7.0H,以7.6%的收率获得间氟碘苯
参考文献:钯纳米颗粒包覆的金属有机骨架催化 Suzuki 均偶联反应合成联芳基化合物
标题:钯纳米颗粒包覆的金属有机骨架催化 Suzuki 均偶联反应合成联芳基化合物
摘要:摘要 Suzuki 均偶联反应极大地加速了苯基硼酸的非均相偶联反应.在这项工作中,设计了一种串联路线,首先一部分苯基硼酸与碘反应生成碘苯,然后另一部分苯基硼酸与碘苯偶联生成联芳基化合物.串联反应由包封有钯纳米颗粒(pd@mofs)的金属有机骨架的双功能多相催化剂催化.这种在苯环之间形成对称cc键的策略具有效率高,易于分离,可回收性好,不添加有毒卤代苯等明显优点.
Doi:10.1016/j.Inoche.2020.108368

专利信息

专利号:US-7652137-B2
优先权日:2003-03-06
标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines
发明人：GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.

专利号:US-6465693-B2
优先权日:1998-02-26
标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

专利号:WO-2023061999-A1
优先权日:2021-10-12
标 题 :Process for preparing a phenolic hydrocarbon
发明人：CORNELLA JOSEP; LE VAILLANT FRANCK
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.

专利号:ES-2355726-T3
优先权日:2003-03-06
标题:SYNTHESIS OF 7-AZAINDOLES AND 7-AZAINDOLINAS REPLACED IN POSITION 5.

专利号:WO-2007002173-A1
优先权日:2005-06-22
标 题:Hiv-1 protease inhibitors, and methods of making and using them
发明人：RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
权利人:UNIV MASSACHUSETTS; RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
摘要:One aspect of the invention relates to the design, synthesis and biological activity of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidine-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. For example, the present invention relates to inhibitors with variations at the P2 phenyloxazolidine and the P2' phenylsulfonamide moieties. Remarkably, compounds with an (S)-enantiomer of substituted phenyloxazolidines at P2 show highly potent inhibitory activities against wild-type HIV-1 protease. In certain embodiments, the inhibitors of the invention have Ki values in low picomolar (pM) range. In certain embodiments, the inhibitors of the invention were shown to be active against a variety of multi-drug resistant (MDR) HIV-1 proteases, each representing different paradigm of drug resistance.