CAS: 1080-06-4; H-Tyr-Ome

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CAS号67-56-1 甲醇 | CAS号60-18-4 L-酪氨酸 | CAS号3417-91-2 L-酪氨酸甲酯盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号13512-31-7 Z-L-酪氨酸甲酯 | CAS号162536-44-9 methyl 2-amino-... | CAS号16870-43-2 L-酪氨酸盐酸盐 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号3978-80-1 N-B°C-L-酪氨酸 | CAS号4985-46-0 L-酪氨酰胺 | CAS号537-49-5 N-甲基-L-酪氨酸 | CAS号51-48-9 左旋甲状腺素 | CAS号4326-36-7 B°C-L-酪氨酸甲酯 | CAS号5034-68-4 L-酪氨醇 | CAS号196808-45-4 Farglitazar | CAS号19519-00-7 methyl 2-[(3-be... | CAS号3410-66-0 D-酪氨酸甲酯 | CAS号60-18-4 L-酪氨酸

L-酪氨酸置于盐酸,Potassium Hydrogencarbonate体系中,用 乙酸乙酯 用作溶剂,化学反应 9.5H,反应生成L-酪氨酸甲酯
参考文献:特定溶剂化作为酪氨酸和(4-羟基苯基)甘氨酸甲酯的 N-化学选择性芳基磺酰化的工具
标题:特定溶剂化作为酪氨酸和(4-羟基苯基)甘氨酸甲酯的 N-化学选择性芳基磺酰化的工具
摘要:L-酪氨酸甲酯和d-(4-羟基苯基)甘氨酸甲酯与芳基磺酰氯直接转化为相应的2-芳基磺酰氨基酯,无需保护酚羟基.该反应在作用作溶剂的 Thf/dmf (8:1) 混合物中进行,并使用冻干的固体碳酸钠作为碱.N-芳基磺酰化以化学选择性方式以非常好的收率(62-85%)发生,没有立体碳中心的外消旋化.Dmf(2.6 Mol/mol 氨基酯)特异性地溶解形成的 N,O-二价阴离子的氧原子,降低其亲核性并显着提高 N-取代的化学选择性.相反,在没有高度配位添加剂的情况下,酚盐阴离子与 2-氨基竞争亲核攻击,而 N,O-二磺酰酯以相应的收率生产.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2003)
Doi:10.1002/ejoc.200300366

专利信息

专利号:US-6825378-B2
优先权日:2003-03-28
标 题 :Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
发明人：KUMAR PRADEEP; FERNANDES RODNEY AGUSTINHO; GUPTA PRITI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-2006154325-A1
优先权日:2005-01-10
标题 :Synthesis of epoxide based inhibitors of cysteine proteases
发明人：BOGYO MATTHEW; VERHELST STEVEN H
权利人:BOGYO MATTHEW; VERHELST STEVEN H
摘要:Epoxide based cysteine protease inhibitors containing peptide derivatives and methods for synthesizing them in sold phase are disclosed. Preferably, an epoxy succinyl “warheadâ€? (for binding to the enzyme) is prepared, having two amino acid residues or residue-like structures on either side. Natural and non-natural amino acids may be used. The present process may be carried out entirely on a solid support, with the proviso that a dipeptide like group is prepared prior to coupling to one side of the supported complex. The method lends itself to more efficient inhibitor synthesis, and may be employed with mixtures of peptide compounds, and various modifications of epoxides to create diverse libraries of inhibitors.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人：JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-5801047-A
优先权日:1992-11-25
标题:Method for making stable extracellular tyrosinase and synthesis of polyphenolic polymers therefrom
发明人：DELLA-CIOPPA GUY RICHARD; GARGER JR STEPHEN JOHN; HOLTZ RICHARD BARRY; MCCULLOCH MICHAEL JAY; SVERLOW GENADIE GLEB
权利人:BIOSOURCE TECH INC
摘要:A process for the in vitro production of chemically modified polyphenolic polymer (PPP). First, stable, highly active extracellular tyrosinase is produced from genetically transformed microorganism such as Streptomyces antibioticus. The tyrosinase is then incubated with a reaction substrate such as 1-tyrosine, hydrolyzed protein, or an oligopeptide in combination with 1-tyrosine. The ratio of the oligopeptide/tyrosine combination as well as variation in the concentration of tyrosinase can be used to modify the color, the molecular size, and the spectral absorbance properties of the PPP produced. Alternatively, or additionally, oxidants such as hydrogen peroxide or hypochlorite can be used to modify the color of the PPP, regardless of the method used to produce the PPP, and the PPP can subsequently be fractionated using molecular weight cut-off ultrafiltration. Organic solvents can also be used in the method of making PPP to produce PPPs having variable but reproducible physical properties.

专利号:US-6140529-A
优先权日:1998-10-22
标 题 :Synthesis of optically active cyclohexylphenylglycolate esters
发明人：BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH
权利人:SEPRACOR INC
摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.