CAS: 1006-23-1; 5-Nitrosopyrimidine-2,4,6-Triamine

上下游产品

CAS号92972-47-9 guanidine; 2-hy... | CAS号593-85-1 碳酸胍 | CAS号1004-38-2 2,4,6-三氨基嘧啶 | CAS号396-01-0 氨苯蝶啶 | CAS号142731-14-4 N-[4-(2,4,7-tri... | CAS号1029-87-4 Pteridine, 2,4-... | CAS号1004-74-6 2,4,5,6-四氨基嘧啶 | CAS号30745-07-4 [1,2,5]oxadiazo... | CAS号18181-93-6 2,4-Pteridinedi... | CAS号7147-37-7 6,8-diamino-1H-... | CAS号7598-40-5 8-thia-2,4,7,9-... | CAS号63110-97-4 naphtho[1,2-g]p... | CAS号5113-30-4 4-methoxytriamterene

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于5-乙基-2-甲基-吡啶体系中,化学反应生成5-亚硝基-2,4,6-三氨基嘧啶
参考文献:Synthesis Of 2-Aminonicotinamides By Raney Nickel Cleavage Of Pyrazolo[3,4-B]-Pyridines1
标题:Synthesis Of 2-Aminonicotinamides By Raney Nickel Cleavage Of Pyrazolo[3,4-B]-Pyridines1
摘要:
Doi:10.1021/ja01519A043

专利信息

专利号:US-4167633-A
优先权日:1977-07-20
标题 :Preparation of 2,4,5,6-tetraaminopyrimidine from 2,4,6-triaminopyrimidine
发明人：MORROW THOMAS J
权利人:US HEALTH EDUCATION & WELFARE
摘要:An improved process for the production of ##STR1## FROM ##STR2## WHICH PRODUCES BUT DOES NOT ISOLATE AN INTERMEDIATE ##STR3## WHICH COMPOUND IS RETAINED IN SITU AND MINIMIZES THE COMPLEX POLYMER FORM OF A THREE-DIMENSIONAL NETWORK OF AZO LINKAGES FORMED BY THE NITROSO AND AMINO GROUPS. These groups, as they appear in the nitroso intermediate, have carcinogenic possibilities. It has been found that the nitroso compound will precipitate as a stirrable slurry if the temperature parameter is kept low at about 0°-20° C. A preferred route for the production of the nitroso compound from the triamino starting material utilizes as reactants 1.0-1.05 moles of sodium nitrite and 1.5 moles of HOAc in water (HCl may be substituted for HOAc). In the second state of this sequential reaction, the reduction of nitroso is carried out by a reducing agent and one preferred agent is sodium dithionite. Catalytic agents such as Raney nickel and hydrazine or nickel salts, e.g., nickel chloride, and sodium borohydride may also be used. The present process is an improvement in part of the technique of Piper and Montgomery, J. Het. Chem., 11:279 (1974), which process is designed specially to produce the antifolate methotrexate as an end product and is an improvement of the method of application Ser. No. 742,450 of Ellard filed Nov. 17, 1976, entitled 'Improved Synthesis of Methotrexate', U.S. Pat. No. 4,080,825.

专利号:US-3159629-A
优先权日:1962-08-07
标 题 :Synthesis of pteridines
发明人：PACHTER IRWIN J
权利人:SMITH KLINE FRENCH LAB

专利号:RU-2047616-C1
优先权日:1993-03-17
标 题 :Method of synthesis of 2,4,6-triamino-6-phenylpteridine

专利号:RU-1624955-C
优先权日:1989-03-29
标题:Method of synthesis of 2,4,6-triamino-5-nitrosopyrimidine