CAS: 996-70-3; N1,N1,N'1,N'1,N2,N2,N'2,N'2-Octamethylethene-1,1,2,2-Tetraamine

上下游产品

CAS号1071-38-1 (二甲氨基亚甲基)二甲基氯化铵 | CAS号5762-56-1 三(二甲氨基)甲烷 | CAS号121-43-7 硼酸三甲酯 | CAS号124-40-3 二甲胺 | CAS号632-22-4 四甲基脲 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号79-38-9 三氟氯乙烯 | CAS号632-22-4 四甲基脲 | CAS号632-14-4 三甲基脲

📜三(二甲氨基)甲烷 反应 72.0H,以73%的收率获得产物四(二甲氨基)乙烯
参考文献:通过四(二甲氨基)乙烯(tdae)还原芳烃重氮盐:有效形成衍生自芳基的产物.
标题:通过四(二甲氨基)乙烯(tdae)还原芳烃重氮盐:有效形成衍生自芳基的产物.
摘要:四(二甲氨基)乙烯(tdae 1)首次被用作一种温和的试剂,用于通过单电子转移(set)途径将芳烃重氮盐还原为芳基自由基中间体.以这种方式产生的芳基环化导致在适当的底物中合成二氢吲哚和吲哚.还报道了衍生自芳烃重氮盐的芳基的级联自由基环化.从反应混合物中去除 Tdae 的氧化副产物相对容易,这使得该方法具有综合吸引力.
DOI:10.3762/bjoc.5.1

专利信息

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-5104944-A
优先权日:1989-07-18
标题:Process for nucleophilic derivatization of materials having an imide group conjugated to an aromatic moiety
发明人：GOLDBERG MARTIN J; MORRIS DANIEL P; VIEHBECK ALFRED
权利人:IBM
摘要:A process for the synthesis of derivatives of materials containing an imide group conjugated to an aromatic moiety to form an ester, a thioester, an amide, a ketone, and silylesters. Electrons are supplied to redox sites to form a reduced imide material. The reduced imide material is contacted with a nucleophile which opens the imide ring of the reduced imide and chemically combines with a carbonyl carbon atom of the open imide ring to form an imide derivative.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-11655342-B2
优先权日:2019-12-31
标 题 :Modified polymethylhydrosiloxane, terminal modified conjugated diene-vinyl aromatic hydrocarbon copolymer and synthesis method for which, rubber composition and tire
发明人：HSIEH KUAN-LIN
权利人:CHI MEI CORP; CHIMEI CORP
摘要:A modified polymethylhydrosiloxane, a terminal modified conjugated diene-vinyl aromatic hydrocarbon copolymer and a synthesis method for which, a rubber composition and a tire are provided. The modified polymethylhydrosiloxane includes a compound represented by a formula (1). n nE is a moiety containing an epoxide group. T is a moiety containing an alkoxysilylalkyl group. A is selected from the group consisting of hydrogen, a moiety containing an alkyl group and a moiety containing an amino group. B is a moiety containing an aryl group. G is a moiety containing an ethyleneoxy group and an alkoxy group. J is a moiety containing an ethyleneoxy group and a hydroxyl group. e=5-45. t=1-4. a+b+g+j is equal to 1 to 595.

专利号:US-2022372235-A1
优先权日:2019-10-08
标题:System and method for polymer synthesis, rubber formulation, and characterization
发明人：TARTAMELLA TIMOTHY L; CHISHOLM BRET; RACKAITIS MINDAUGAS
权利人:TARTAMELLA TIMOTHY L; FRANKS WILLIAM; CHISHOLM BRET J; RACKAITIS MINDAUGAS; BRIDGESTONE CORP
摘要:A method for rubber formulating and characterizing, the method comprising (i) providing a plurality of rubber samples including at least three rubber samples each contained within a container; (ii) introducing a compounding additive to at least one of the samples within the plurality of rubber samples to thereby form a plurality of rubber formulations each contained within a container; (iii) mixing at least one of the samples of the plurality of rubber formulations under high-shear conditions to thereby form a plurality of vulcanizable compositions; and (iv) analyzing at least one of the samples plurality of vulcanizable compositions to thereby characterize the compositions of the plurality, where at least one or the plurality of the rubber samples, the plurality of rubber formulations, the plurality of vulcanizable compositions are transferred to a subsequent step through an automated transfer.