CAS: 85-36-9; 3-Acetamido-2,4,6-Triiodobenzoic Acid

上下游产品

3-amino-2,4,6-triiodobenzoic acid acetic anhydride 3-amino-2,4,6-triiodobenzoic acid

乙酸酐,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 醋碘苯酸
参考文献:Labelling Of Radiographic Contrast Media With Iodine-131
标题:Labelling Of Radiographic Contrast Media With Iodine-131
摘要:造影剂的迅速发展和普遍接受是伦琴诊断学的突出成就之一.伦琴造影剂通常是苯或吡啶的二碘或三碘衍生物,含有影响溶解度的其他取代基.最广泛使用的造影剂是3,5-二碘-4-吡啶-N-乙酸的二乙醇胺盐("Iodopyracet","Diodrast","Diodone","Ioduron "等),以及n-甲基-3,5-二碘-酞胺酸的二钠盐("Neo-Iopax","Iodoxyl","Uropac "等).一种新的尿毒性化合物是 3-乙酰氨基-2,4,6-三碘苯甲酸钠,被称为 "Triopac","Urokon","Triumbren "和二乙酰氨基-2,4,6-三碘苯甲酸,其甲基葡萄糖酸盐被称为 "Urografin".肝脏造影剂的代表是 N,N²-二乙酰基-双(3-氨基-2,4,6-三碘苯甲酸)甲基氨基葡萄糖酸盐("Biligrafin "或 "Cholografin")和 2-乙基-3-(3-氨基-2,4,6-三碘苯基)丙酸("Cistobil "或 "Telepaque").
DOI:10.1038/1831474A0

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2011104052-A1
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres
发明人：BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
权利人:UNIV JOHNS HOPKINS
摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.

专利号:US-2016138027-A1
优先权日:2013-03-14
标 题:Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
发明人：GAN LIN; MEYER TOBIAS
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods for treating diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mTORC1) are disclosed. The invention is based in part on the discovery that protein mediator of amino acid signaling to mTOR (MORTOR) is involved in amino acid-induced translocation of mTORC1 to lysosomes where MORTOR forms a signaling complex with mTORC1, Ragulator, and Rag GTPases, which controls protein synthesis. In particular, the invention relates to the use of antagonists of MORTOR for treating diseases and conditions associated with dysregulation of mTORC1. Downregulation of expression of MORTOR by RNA interference has been shown to reduce cell proliferation of cancerous cells and may be useful for treating cancer.

专利号:US-2022233727-A1
优先权日:2019-06-13
标题:Surface enhanced raman scattering nanoparticles and their use in detecting and imaging oxidative stress
发明人：THAKOR AVNESH S; RAZAVI MEHDI
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Surface enhanced Raman scattering (SERS) nanoparticles and methods of using them for detecting reactive oxygen species are disclosed. In particular, methods of using SERS nanoparticles to detect and quantify reactive oxygen species Synthesis and monitor oxidative stress and disease-relevant changes in levels of reactive oxygen species are provided.

专利号:EP-2229147-A2
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres