CAS: 79427-88-6; 2-Hydroxy-5-(Trifluoromethyl)Benzoic Acid

上下游产品

2-甲氧基-5-三氟甲基苯甲酸 2-Methoxy-5-(Trifluoromethyl)Benzoic Acid 01/01/4864
2-甲氧基-5-(三氟甲基)苯甲酸甲酯 Methyl 2-Methoxy-5-(Trifluoromethyl)Benzoate 177174-47-9
2-(甲氧基甲氧基)-5-(三氟甲基)苯甲酸 2-Methoxymethoxy-5-(Trifluoromethyl)Benzoic Acid 368422-27-9
2-羟基-5-(三氟甲基)苯甲醛 2-Hydroxy-5-(Trifluoromethyl)Benzaldehyde 210039-65-9
3-三氟甲基苯甲酸 3-(Trifluoromethyl)Benzoic Acid 454-92-2

📜3-三氟甲基苯甲酸置于potassium Hydrogenphosphate Trihydrate,双氧水,Palladium Diacetate,2-Methyl-2-(6-Oxo-1,6-Dihydropyridin-2-yl) Propanoic Acid体系中,用 水,乙腈 作为反应溶剂,化学反应 24.0H,以81%的收率获得产物2-羟基-5-三氟甲基苯甲酸
参考文献:室温下用 H2O2 水溶液进行配体驱动的 C-h 羟基化
标题:室温下用 H2O2 水溶液进行配体驱动的 C-h 羟基化
摘要:随着过去十年中大量pd(II)催化的天然底物c-H活化反应的发展,开发能够在安全实用的条件下使用绿色氧化剂的催化剂已成为一个日益重要的挑战.值得注意的是,Pd(II) 催化剂与可持续含水 H2O 2的相容性一直是包括瓦克型氧化在内的催化领域的长期挑战.我们在此报道了一种双功能双齿羧基吡啶酮 (Carboxpyridone) 配体,该配体能够使用工业兼容的氧化剂过氧化氢水溶液 (35% H2O)在室温下 Pd 催化的各种苯甲酸和苯乙酸的 C-H 羟基化反应.2).仅使用 1 Mol% Pd 催化剂负载的布洛芬 (206 G) 的 1000 Mmol 规模反应证明了该方法的可扩展性.通过产品的衍生化以及从使用该方法制备的苯酚中间体合成多氟天然产物古美斯坦和紫檀烯,进一步说明了该协议的实用性.
DOI:10.1021/jacs.2C08332

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:FR-2735771-A1
优先权日:1995-06-22
标 题:PROCESS FOR THE SYNTHESIS OF HYDROXYARYLCARBOXYLIC ACIDS CARRIING ELECTROATTRACTOR (S) AND / OR LIPOPHILIC GROUP (S)