CAS: 710-11-2; 2-Oxo-4-Phenylbutanoic Acid

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CAS号1327337-63-2 lithium 2-oxo-4... | CAS号64920-29-2 2-氧代-基丁酸乙酯 | CAS号125582-89-0 bis(prop-2-enyl... | CAS号17451-19-3 2-氧代-4-苯基-3-丁酸 | CAS号100-52-7 苯甲醛 | CAS号15814-45-6 allyl 3-phenylp... | CAS号83402-87-3 2-氧代-4-苯基丁酸甲酯 | CAS号7226-82-6 (RS)-2-hydroxy-... | CAS号103-63-9 β-溴苯乙烷 | CAS号943-73-7 L-高苯丙氨酸 | CAS号501-52-0 3-苯丙酸 | CAS号29678-81-7 (R)-2-羟基-4-苯丁酸 | CAS号115016-95-0 (S)-2-羟基-4-苯丁酸 | CAS号83402-87-3 2-氧代-4-苯基丁酸甲酯 | CAS号64920-29-2 2-氧代-基丁酸乙酯 | CAS号76547-98-3 赖诺普利 | CAS号85955-59-5 (R)-赖诺普利钠盐 | CAS号76420-72-9 依那普利拉 | CAS号1012-05-1 DL-高苯丙氨酸

2-氧代-4-苯基丁酸甲酯置于氢氧化钾体系中,用 乙醇,水 作为反应溶剂,化学反应生成 2-氧代-4-苯基丁酸
参考文献:Asymmetric Aerobic Oxidation Of α-Hydroxy Acid Derivatives By C4-Symmetric,Vanadate-Centered,Tetrakisvanadyl(V) Clusters Derived From N-Salicylidene-α-Aminocarboxylates
标题:Asymmetric Aerobic Oxidation Of α-Hydroxy Acid Derivatives By C4-Symmetric,Vanadate-Centered,Tetrakisvanadyl(V) Clusters Derived From N-Salicylidene-α-Aminocarboxylates
摘要:A Series Of Chiral Vanadyl(V) Methoxides Bearing 3-T-Butyl-5-Substituted N-Salicylene-L-Valinate And L-T-Leucinate As Chiral Auxiliaries Has Been Prepared. In All Cases Except The 3,5-Di-T-Butyl Analogue,They Exist As Monomers Both In Solution And In The Single Crystal State. In The Case Of The 3,5-Di-T-Butyl Analogue,The Architectural Nature Of The Vanadyl(V) Complex Highly Depends On The Base Used During The Complex Formation Event. A Pentanuclear C-4-Symmetric Complex Was Formed When Potassium Salts Were Employed Instead Of The Corresponding Sodium Salts. A Central Vanadate(V) Unit Serves To Grip Four Identical Chiral Monomeric Vanadyl(V) Units Together,By Which A Potassium Ion Sits On Top Of The Four Flanking Units Through Carbonyl Coordinations And Serves To Hold The Whole Cluster By Cooperation With The Central Vanadate(V) Unit. In Comparison With The Corresponding Monomeric Vanadyl(V) Methoxide Complex,The Cluster Complex Was Utilized To Facilitate The Asymmetric Aerobic Oxidations Of Various Racemic Alpha-Hydroxyesters,-Amides,And-Thioesters With Excellent Selectivity Factors (K(Rel) 40 To >500).
DOI:10.1021/jo070575F

专利信息

专利号:WO-2023198025-A1
优先权日:2022-04-11
标题:Synthesis method and synthesis device for organic nitrogen-containing compound
发明人：LI GUANGQIN; Liao Peisen; XIAN JIAHUI; LI SUISHENG; ZHANG YAWEI
权利人:UNIV SUN YAT SEN
摘要:The present invention relates to the field of organic synthesis, specifically to a synthesis method and synthesis device for an organic nitrogen-containing compound. Provided in the present invention is a synthesis method for an organic nitrogen-containing compound. In the method provided in the present invention, a porous carbon material is used as a catalyst, organic nitrogen-containing compounds such as an oxime, an amine, a nitrile and an amino acid are synthesized by means of an electro-catalysis method, byproducts are unlikely to generate, and the method is safe and environmentally friendly. Experiments show that organic nitrogen-containing compounds such as an amino acid, an oxime, an amine and a nitrile are successfully synthesized by using the method of the present invention, and the method has good Faraday efficiency and yield. In the present application, the synthesis of the above organic nitrogen-containing compounds can be realized by using nitrogen oxide waste gas or waste water as a raw material; and by converting the nitrogen oxide waste gas or waste water, the utilization of waste is realized, and the benefits are maximized. Further provided in the present invention is a synthesis device for an organic nitrogen-containing compound, which device is used for solving the defects of high energy consumption, long consumption time, and complex product separation and purification of existing synthesis methods.

专利号:US-6033882-A
优先权日:1994-07-07
标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
发明人：HOLBROOK JOSEPH JOHN; WILLIS CHRISTINE LOUISE; JOHNSEN KEYJI; HATELEY MARTIN JOHN
权利人:GENZYME CORP
摘要:PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.

专利号:US-6146859-A
优先权日:1999-08-27
标题 :Facile synthesis of L-homophenylalanine by equilibrium shift enzymatic reaction using engineered tyrosine aminotransferase
发明人：CHEN SHUI-TEIN; TSENG MIN-JEN; SOOKKHEO BOONYARAS
权利人:ACADEMIA SINICA
摘要:A process for producing L-homophenylalanine comprises the step of reacting 2-oxo-4-phenylbutyric acid with a L-amino acid in the presence of tyrosine aminotransferase in a reaction solution to produce L-homophenylalanine.

专利号:US-5256552-A
优先权日:1988-02-08
标题 :Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
发明人：MATSUYAMA AKINOBU; NIKAIDO TERUYUKI; KOBAYASHI YOSHINORI
权利人:DAICEL CHEM
摘要:2-Oxo-4-phenylbutyric acid is treated with a microorganism, which has been optionally treated, capable of asymmetrically reducing 2-oxo-4-phenylbutyric acid into either (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid, and the (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid thus produced is recovered to thereby give optically active 2-hydroxy-4-phenylbutyric acid. n The optically active 2-hydroxy-4-phenylbutyric acid is an important intermediate in the synthesis of various drugs such as a remedy for hypertension.

专利号:US-5686275-A
优先权日:1991-12-23
标 题 :Synthesis of homochiral 2-hydroxy acids
发明人：CASEY GUY; LEE THOMAS; LEE ADMINISTRATOR VICTOR; LEE ADMINISTRATRIX EILEEN ANN
权利人:GENZYME LTD
摘要:PCT No. PCT/GB92/02396 Sec. 371 Date Aug. 26, 1994 Sec. 102(e) Date Aug. 26, 1994 PCT Filed Dec. 23, 1992 PCT Pub. No. WO93/13215 PCT Pub. Date Jul. 8, 1993A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and R'' represents hydrogen, halogen or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and M represents hydrogen or a salt-forming moiety; characterized in that it comprises reducing a corresponding 2-keto carboxylic acid or salt thereof using a (R)- or (S)-2-oxo carboxylic acid dehydrogenase, inter alia, is disclosed.

专利号:US-5371014-A
优先权日:1988-02-12
标题 :Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
发明人：MATSUYAMA AKINOBU; NIKAIDO TERUYUKI; KOBAYASHI YOSHINORI
权利人:DAICEL CHEM
摘要:An optically active 2-hydroxy acid derivative is produced by treating a 2-oxo acid derivative with a microorganism, which has been optionally treated, capable of asymmetrically reducing said 2-oxo acid derivative into an optically active (R)- or (S)-2-hydroxy acid derivative represented by the formula (II) and recovering the optically active (R)- or (S)-hydroxy acid derivative thus formed. Optically active 2-hydroxy acid derivatives are important intermediates in the synthesis of various drugs such as a remedy for hypertension.