CAS: 68379-03-3; Clofiliumphosphate
- 英文名称Clofiliumphosphate
- 中文名称磷酸氯非铵
- IUPAC名称N-(4-(4-chlorophenyl)butyl)-N,N-diethylheptan-1-aminium phosphate
- 其它别名Clofilium Phosphate; N,N-Diethyl-N-Heptyl-4-Chlorobenzenebutan-1-Aminium; Clofilium
- CAS编号68379-03-3
- FDA UNII编号:O1IXD77P8S
- 分子式:C63H111Cl3N3O4P分子量:1111.93
- 产品CID: 1673928
- 同类组份化合物CAS68379-02-2 (cation)92953-10-1 (Tosylate)68379-03-3 (Phosphate)
- 产品分类无机化工 → 无机盐 → 无机铵盐
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2903919090-氯苯
2903991000-对氯甲苯
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专利信息
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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主要参考文献
1: Șterbuleac D, Maniu CL. Computer Simulations Reveal a Novel Blocking Mode of the hERG Ion Channel by the Antiarrhythmic Agent Clofilium. Mol Inform. 2018 Jul;37(6-7):e1700142. doi: 10.1002/minf.201700142. Epub 2018 Feb 21. doi: 10.1016/j.yjmcc.2018.02.001. Epub 2018 Feb 2.
3: Chauvin C, Leruste A, Tauziede-Espariat A, Andrianteranagna M, Surdez D, Lescure A, Han ZY, Anthony E, Richer W, Baulande S, Bohec M, Zaidi S, Aynaud MM, Maillot L, Masliah-Planchon J, Cairo S, Roman-Roman S, Delattre O, Del Nery E, Bourdeaut F. High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors. Cell Rep. 2017 Nov 14;21(7):1737-1745. doi: 10.1016/j.celrep.2017.10.076. doi: 10.1093/cvr/cvx063.
5: Papp H, Sarusi A, Farkas AS, Takacs H, Kui P, Vincze D, Ivany E, Varro A, Papp JG, Forster T, Farkas A. Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits. J Physiol Pharmacol. 2016 Oct;67(5):731-737. doi: 10.1111/cbdd.12797. Epub 2016 Jul 11. doi: 10.1093/hmg/ddv509. Epub 2015 Dec 21. doi: 10.1002/prp2.160. Epub 2015 Jul 31.
合成参考文献
摘要:New Drugs Annual: Cardiovascular Drugs., 2(103), 1984
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