CAS: 68314-38-5; (6R,7R)-Benzhydryl 7-(4-Methylbenzamide)-3-(Chloromethyl)-7-Methoxy-8-Oxo-5-Oxa-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

英文名称(6R,7R)-Benzhydryl 7-(4-Methylbenzamide)-3-(Chloromethyl)-7-Methoxy-8-Oxo-5-Oxa-1-Aza-Bicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
中文名称拉氧头孢杂质
CAS编号68314-38-5
分子式:C30H27ClN2O6分子量:547.0
产品CID: 1672902
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: SJLVZMPGYLBPCT-IHLOFXLRSA-N
1S/C30H27ClN2O6/c1-19-13-15-22(16-14-19)26(34)32-30(37-2)28(36)33-24(23(17-31)18-38-29(30)33)27(35)39-25(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-16,25,29H,17-18H2,1-2H3,(H,
计算化学: 氢键受体数6.0氢键供体数1.0可旋转键数9.0

MSDS等安全信息

上下游产品

6β-(4-toluamido)penicillanic acid diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]°Ctane-2-carboxylate (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]°Ct-2-ene-2-carboxylate

合成工艺路线路线简述

📜Diphenylmethyl 6β-(4-Toluamido)Penicillanate置于吡啶,Sodium Tungstate,三甲基氯硅烷,次氯酸叔丁酯,双氧水,氯,碳酸氢钠,二乙胺,三乙胺,三苯基膦体系中,用甲醇,二氯甲烷,水,乙酸乙酯作为反应溶剂,化学反应生成拉氧头孢杂质
参考文献:Design,Synthesis And Antibacterial Activity Of Novel 1-Oxacephem Analogs
标题:Design,Synthesis And Antibacterial Activity Of Novel 1-Oxacephem Analogs
摘要:A Series Of 1-Oxacephem Analogs Were Synthesized And Their Antibacterial Properties Against Five Strait Is Of Gram-Positive And Gram-Negative Bacteria Were Evaluated In Vitro While Ceftazidine Was Selected As Control. Some Of The Tested Compounds,Compound 12C In Particular,Showed More Active Against Three Selected Strains Than The Standard. (C) 2012 Yong Wu. Published By Elsevier B.V,On Behalf Of Chinese Chemical Society. All Rights Reserved.
DOI:10.1016/j.Cclet.2012.01.014