CAS: 6574-97-6; 2,3-Dichlorobenzonitrile

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CAS号5980-24-5 2,3-二氯苯甲酰胺 | CAS号544-92-3 氰化亚铜 | CAS号608-27-5 2,3-二氯苯胺 | CAS号4414-54-4 2,3-二氯苯甲醛肟 | CAS号151-50-8 氰化钾 | CAS号50-45-3 2,3-二氯苯甲酸 | CAS号2905-60-4 2,3－二氯苯甲酰氯 | CAS号32768-54-0 2,3-二氯甲苯 | CAS号56041-57-7 2,3-二氯苯乙酮 | CAS号94087-40-8 3-氯-2-氟苯甲腈 | CAS号39226-95-4 2,3-二氯苄胺 | CAS号50-45-3 2,3-二氯苯甲酸 | CAS号2905-60-4 2,3－二氯苯甲酰氯 | CAS号84057-84-1 拉莫三嗪 | CAS号5980-24-5 2,3-二氯苯甲酰胺 | CAS号75473-09-5 2,3-二氯苯甲酰基乙腈 | CAS号261761-55-1 2,3-二氯-N-羟基苯羧酰亚胺 | CAS号175205-12-6 5-(2,3-二氯苯基)-1H-四唑

2,3-二氯苯甲酸置于ammonium Hydroxide,草酰氯,三氯氧磷体系中,用 乙酸乙酯,甲苯 作为反应溶剂,化学反应 6.0H,反应生成 2,3-二氯苯腈
参考文献:Structure−activity Studies For A Novel Series Of Tricyclic Substituted Hexahydrobenz[e]Isoindole α1A Adrenoceptor Antagonists As Potential Agents For The Symptomatic Treatment Of Benign Prostatic Hyperplasia (Bph)
标题:Structure−activity Studies For A Novel Series Of Tricyclic Substituted Hexahydrobenz[e]Isoindole α1A Adrenoceptor Antagonists As Potential Agents For The Symptomatic Treatment Of Benign Prostatic Hyperplasia (Bph)
摘要:In Search Of A Uroselective Agent That Exhibits A High Level Of Selectivity For The Alpha(1A) Receptor,A Novel Series Of Tricyclic Hexahydrobenz[e]Isoindoles Was Synthesized. A Generic Pharmacophoric Model Was Developed Requiring The Presence Of A Basic Amine Core And A Fused Heterocyclic Side Chain Separated By An Alkyl Chain. It Was Shown That The 6-Ome Substitution With R,R Stereochemistry Of The Ring Junction Of The Benz[e]Isoindole And A Two-Carbon Spacer Chain Were Optimal. In Contrast To The Highly Specific Requirements For The Benz[e]Isoindole Portion And Linker Chain,A Wide Variety Of Tricyclic Fused Heterocyclic Attachments Were Tolerated With Retention Of Potency And Selectivity. In Vitro Functional Assays For The Alpha(1) Adrenoceptor Subtypes Were Used To Further Characterize These Compounds,And In Vivo Models Of Vascular Vs Prostatic Tone Were Used To Assess Uroselectivity.
DOI:10.1021/jm990567U