CAS: 623-48-3; Ethyl 2-Iodoacetate

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CAS号105-36-2 溴乙酸乙酯 | CAS号4071-88-9 三甲基硅乙酸乙酯 | CAS号620-73-5 氯乙酸苯酯 | CAS号459-72-3 氟乙酸乙酯 | CAS号34982-24-6 ethyl 2-triphen... | CAS号105-39-5 氯乙酸乙酯 | CAS号64-17-5 乙醇 | CAS号64-69-7 碘乙酸 | CAS号665-83-8 ethyl-(1,1-difl... | CAS号624-74-8 二碘乙炔 | CAS号72656-47-4 (+)-乙基 (R)-3-羟基... | CAS号33401-74-0 (S)-3-羟基-3-苯基丙酸乙酯 | CAS号5764-85-2 3-羟基-3-苯基丙酸乙酯 | CAS号147283-76-9 ethyl 2-(3-nitr... | CAS号14271-34-2 3-(4-methylphen... | CAS号459-72-3 氟乙酸乙酯 | CAS号201221-74-1 ethyl 2-iodo-3-... | CAS号19169-94-9 (E)-3-(4-methox... | CAS号539-88-8 乙酰丙酸乙酯 | CAS号817-95-8 乙氧基乙酸乙酯

📜溴乙酸乙酯置于sodium Iodide体系中,用 丙酮 作为反应溶剂,以97%的收率获得产物碘代醋酸乙酯
参考文献:双锁定9 E,11Z视网膜模型系统7 E,13E-11,19-10,20-二甲基氨基视网膜及其13 Z异构体的合成和光谱表征
标题:双锁定9 E,11Z视网膜模型系统7 E,13E-11,19-10,20-二甲基氨基视网膜及其13 Z异构体的合成和光谱表征
摘要:使用新型合成子2-(二乙氧基膦基)-5,5-二甲氧基己腈,由β-紫罗兰酮制备了7E,13E-11,19-10,20-二甲基氨基视网膜(1)及其13 Z异构体2.该合成子还用于以β-紫罗兰酮为原料,以高收率制备7E,9E,13E-10,20-甲基视黄醛(3)及其13 Z异构体4.讨论了这些化合物的光谱分析(质量,1 H和13 C NMR和uv / Vis).甲醇桥的引入导致最小的空间和电子变化.从1和2到达的光平稳态具有13 Z形式2为主要成分.这是极少数具有z形作为光固定态主要成分的分子之一.1和2对13-C14-C双键的酸催化的异构化非常敏感.11,19-甲醇桥的存在是造成这种有效的ze异构化的原因.
DOI:10.1002/recl.19921110206

专利信息

专利号:US-7390931-B2
优先权日:2004-04-01
标 题:Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis
发明人：HOGE II GARRETT STEWART
权利人:PFIZER
摘要:Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. When bound to transition metals such as rhodium, the disclosed P-chirogenic phospholanes may be used as catalysts in asymmetric synthesis of valuable pharmaceutical chemical entities, including pregabalin.

专利号:US-2008312430-A1
优先权日:2004-10-20
标题:Method of Preparing or Synthesizing Polyazamacrocycle Derivatives
发明人：CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention relates to novel processes for the synthesis of polyazamacrocycle derivatives. Furthermore, the present invention relates to novel polyazamacrocycle derivatives as well as novel intermediates for the synthesis of said polyazamacrocycle derivatives.

专利号:US-6482851-B1
优先权日:1998-02-04
标题 :Synthesis of dysidiolide and uses thereof
发明人：DANISHEFSKY SAMUEL J; MAGNUSON STEVEN R; ROSEN NEAL; SEPP-LORENZINO LAURA
权利人:SLOAN KETTERING INST CANCER; UNIV COLUMBIA
摘要:This invention provides a process for the preparation of a racemic mixture of dysidiolide a method for inhibiting growth of cancerous cells comprising contracting an amount of the racemic mixture of dysidiolide effective to inhibit the growth of said cells. Further provided is a method for treating cancer in a subject which comprises administering to the subject a therapeutically effective amount of the racemic mixture of dysidiolide.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-8592587-B2
优先权日:2007-03-21
标题 :Transannular rearrangement of activated lactams
发明人：MARTINEZ JEAN; DEWYNTER GEORGES; FARRAN DANIEL
权利人:MARTINEZ JEAN; DEWYNTER GEORGES; FARRAN DANIEL; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER I
摘要:The disclosure relates to a method for the synthesis of a compound of the following formula (I) in which: R1 and R2 are independently an N-protective group; R3 is a hydrogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 arylalkyl group, a C 2 -C 6 alkenyl group, or a alkoxycarbonylalkyl group; Y is a —C(HR4)- group in which R4 is a hydrogen atom, a C 1 -C 6 alkyl group, an aryl group, a C 1 -C 6 arylalkyl group, or a C 2 -C 6 alkenyl group; or an orthophenylene group.

专利号:WO-2014203045-A1
优先权日:2013-06-20
标 题:A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
发明人：ROY BHAIRABNATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG; PISE VIJAY SADASHIV; RUPANWAR MANOJ
权利人:LUPIN LTD
摘要:The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -butyl (3R,5S)-6-oxo-3,5-dihydroxy- 3,5-O-isopropylidene-hexanoate [I].