CAS: 5345-42-6; 1-Methoxy-3-Methyl-2-Nitrobenzene

上下游产品

CAS号50868-73-0 2-甲氧基-6-甲基苯胺 | CAS号4920-77-8 2-硝基间甲酚 | CAS号74-88-4 碘甲烷 | CAS号91-23-6 2-硝基苯甲醚 | CAS号1347760-96-6 [13C]methyl-dim... | CAS号106776-17-4 Trimethylsulfon... | CAS号100-84-5 间甲基苯甲醚 | CAS号2181-42-2 三甲基碘代磺酸 | CAS号33234-36-5 2-氯-3-甲氧基苯甲酸 | CAS号3189-22-8 7-甲氧基吲哚 | CAS号50868-73-0 2-甲氧基-6-甲基苯胺 | CAS号644961-69-3 4-chloro-2-meth... | CAS号4920-80-3 3-甲氧基-2-硝基苯甲酸 | CAS号3177-80-8 2-氨基-3-甲氧基苯甲酸 | CAS号4920-77-8 2-硝基间甲酚 | CAS号20876-31-7 3-甲氧基-2-硝基苯乙酸 | CAS号602-00-6 3-羟基-2-硝基苯甲酸 | CAS号548-93-6 3-羟基-2-氨基苯甲酸

间甲基苯甲醚置于二硫化碳,氯磺酸,Sodium Hydroxide,氯仿,五氯化磷,硫酸,硝酸体系中,化学反应生成 3-甲基-2-硝基苯甲醚
参考文献:Haworth; Lapworth,Journal Of The Chemical Society,1923,Vol. 123,P. 2989
标题:Haworth; Lapworth,Journal Of The Chemical Society,1923,Vol. 123,P. 2989

专利信息

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人：NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.