CAS: 51598-60-8; Cimetropium Bromide

该化合物是一种四氟铵抗胆碱酯酶剂,主要用作胃肠道和腹腔紊乱的聚氨酯剂,通过竞争抑制肌肉胃肠胃炎和胆碱酯酶受体,从而减少消化道的肌肉萎缩.该化合物显示胃肠滑动肌肉具有高度选择性,与非选择性抗胆碱酯酶相比,尽可能减少系统性副作用.其四氟结构限制了...

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    专利号:US-7993390-B2
    优先权日:2002-02-08
    标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
    发明人:MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
    权利人:BOSTON SCIENT SCIMED INC
    摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:CN-101208345-B
    优先权日:2005-05-25
    标 题 :(S) -N-methylnaltrexone, method of synthesis and pharmaceutical use thereof
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    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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