专利号:UA-5633-U 优先权日:2004-07-23 标 题:4 (4-H-ALCOXYBENZOYLOXY) -3-BROMOBENZOIC ACIDS AS INTERMEDIATES FOR THE SYNTHESIS OF LIQUID CRYSTAL MATERIALS
专利号:US-8816121-B2 优先权日:2010-06-09 标 题:GLP-1 receptor stabilizers and modulators 发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; HUANG LIMING; TAMIYA JUNKO; GRIFFITH MARK T; FOWLER THOMAS; NOVAK ANDREW; KNAGGS MICHAEL; MEGHANI PREMJI 权利人:RECEPTOS INC 摘要:Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analysis of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
专利号:US-9700543-B2 优先权日:2011-05-31 标题 :GLP-1 receptor stabilizers and modulators 发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD 权利人:CELGENE INT II SÀRL 摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.
参考文献:10.1134/s1070363218120174 摘要:Novikova NS, Kilimenchuk ED, Kondrat’eva RV, Teslyuk OI, Zheltvai II. Synthesis of Mesomorphic Derivatives of Methyl 2,4-Dihydroxybenzoate and Spectral and Luminescence Properties of Their Lanthanide Complexes. Russian Journal of General Chemistry. 2018 Dec;88(12):2564–71. doi: 10.1134/s1070363218120174.