CAS: 40473-07-2; 2-Bromo-6-Methoxypyridine

相似化合物

1256807-52-9 4645-11-8 1196154-35-4

上下游产品

CAS号626-05-1 2,6-二溴吡啶 | CAS号124-41-4 甲醇钠 | CAS号67-56-1 甲醇 | CAS号27992-32-1 2-溴-6-羟基吡啶 | CAS号74-88-4 碘甲烷 | CAS号1628-89-3 2-甲氧基吡啶 | CAS号112197-01-0 (2-methoxypyrid... | CAS号1060806-62-3 6-溴-2-甲氧基烟酸 | CAS号1111112-94-7 6-(2,6-difluoro... | CAS号54221-96-4 6-甲氧基吡啶-2-甲醛 | CAS号5140-72-7 2-溴-6-氯吡啶 | CAS号620-83-7 4-甲基二苯甲烷 | CAS号1326217-44-0 2-methoxy-6-(4-... | CAS号83621-01-6 6-甲氧基吡啶-2-甲腈 | CAS号6628-77-9 5-氨基-2-甲氧基吡啶

2,6-二溴吡啶置于sodium Methylate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.0H,以93%的收率获得产物2-溴-6-甲氧基吡啶
参考文献:一些卤代吡啶与甲醇盐和甲硫醇盐离子在二甲基甲酰胺中的反应
标题:一些卤代吡啶与甲醇盐和甲硫醇盐离子在二甲基甲酰胺中的反应
摘要:2,6-和2,5-二溴吡啶和2,3-和3,5-二氯吡啶与异丙硫醇钠和甲硫醇钠的反应根据实验条件提供单取代或双取代的产物.相同的吡啶与甲醇钠反应,得到非常好收率的单取代产物.仅在2,6-二溴-和3,5-二氯吡啶中容易发生双取代.还描述了从卤代甲氧基吡啶或卤代硫代甲氧基吡啶开始的一些甲氧基硫代甲氧基吡啶的合成.双(烷硫基)吡啶可被hmpa中的钠裂解,得到双(巯基)吡啶.
DOI:10.1016/s0040-4020(01)96539-1

专利信息

专利号:US-6252079-B1
优先权日:1993-06-30
标 题 :Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; BOM DAVID
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursoris reacted with an aryl isonitrile having the formulawherein X is Br or I, and R4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R16 is H, a C1-C6 alkoxy group, agroup wherein p is an integer between 4 and 12, or a C1-C12 acyclic dialkylamino group. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-6982333-B2
优先权日:1993-06-30
标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; JOSIEN HUBERT; KO SUNG BO
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:WO-2022170218-A1
优先权日:2021-02-05
标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
发明人：QIN TIAN; YANG YANGYANG; TSIEN JET
权利人:UNIV TEXAS
摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2004063947-A1
优先权日:1993-06-30
标 题:Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof

专利号:US-6211371-B1
优先权日:1993-06-30
标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof