CAS: 38350-87-7; 4-Heptylbenzoic Acid

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CAS号586-76-5 对溴苯甲酸 | CAS号13125-66-1 庚基溴化镁 | CAS号49763-67-9 4-正庚基苯甲醛 | CAS号1078-71-3 庚基苯 | CAS号79-37-8 草酰氯 | CAS号50606-96-7 4-庚基苯甲酰氯 | CAS号50606-96-7 4-庚基苯甲酰氯 | CAS号67589-92-8 4-heptylcyclohe...

📜庚基苯置于jones Reagent体系中,用 丙酮,三氟乙酸 用作溶剂,化学反应 0.5H,反应生成对正庚基苯甲酸
参考文献:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
标题:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
摘要:(p-戊基肉桂酰基)邻氨基苯甲酸(3A)对ltd4-诱导的豚鼠回肠平滑肌收缩和ltc4诱导的豚鼠支气管收缩具有中等程度的拮抗活性.对3A的疏水部分(肉桂酰基部分)和亲水部分(邻氨基苯甲酸酯部分)进行了修饰.揭示了一系列的8-(苯甲酰基氨基)-2-四唑-5-基-1,4-苯并二恶烷和8-(苯甲酰基氨基)-2-四唑-5-基-4-氧代-4H-1-苯并吡喃.白三烯c4和d4的有效拮抗剂.在这两个系列中,Ono-Rs-347(18K)和ono-Rs-411(19H)分别是最有效和口服活性的拮抗剂.讨论了构效关系.
Doi:10.1021/jm00396A013

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-7320993-B1
优先权日:1997-12-17
标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
发明人：BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL
权利人:ASTELLAS DEUTSCHLAND GMBH
摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.

专利号:WO-2013015918-A1
优先权日:2011-07-22
标 题 :Method of regioselective synthesis of substituted benzoates