CAS: 38243-03-7; (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-Hydroxy-17-((R)-2-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
该化合物是一种天然化合物,来自人参,具体而言,是一种人参,是一种以其各种药理特性而闻名的血清沙朋因人参,其特征是分子配方,其结构复杂,典型的是一种糖质类固醇骨质.Rg3以两种立体异构形式存在,R型具有生物活性.该化合物因其潜在的健康利益而得到承认,包括抗癌,抗炎和...
- 英文名称(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-Hydroxy-17-((R)-2-Hydroxy-6-Methylhept-5-En-2-yl)-4,4,8,10,14-Pentamethylhexadecahydro-1H-Cyclopenta[a]Phenanthren-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
- 中文名称人参皂甙 Rg3
- IUPAC名称(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((R)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- 其它别名(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-Hydroxy-17-[(2R)-2-Hydroxy-6-Methyl-Hept-5-En-2-Yl]-4,4,10,13,14-Pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-Yl]Oxy]-6-(Hydroxymethyl)Oxan-3-Yl]Oxy-6-(Hydroxymethyl)Oxane-3,4,5-Triol; (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-Hydroxy-17-[(2R)-2-Hydroxy-6-Methylhept-5-En-2-Yl]-4,4,10,13,14-Pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-Yl]Oxy]-6-(Hydroxymethyl)Oxan-3-Yl]Oxy-6-(Hydroxymethyl)Oxane-3,4,5-Triol; Ginsenoside Rg3(R-Form)(P); Ginsenoside Rg3 (R-); Ginsenoside Rg3 Rh2; Ginseonoside Rg3; 20(R)Ginsenoside Rg3 20(R); 20(R)-Propanaxadiol
- CAS编号38243-03-7
- MFCD编号:MFCD11045225
- FDA UNII编号:U9LS0C9SWP
- 分子式:C42H72O13分子量:785.03
- 产品CID: 1393824
- 产品分类Chemistry → Asymmetric Synthesis → Chiral Building Blocks | Ethers | Tetrahydropyrans | Aliphatic Cyclic Hydrocarbons | Inhibitors/Agonists → Immunology/Inflammation → ROS | Alcohols | Alkenyls
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: RWXIFXNRCLMQCD-CZIWJLDFSA-N
- VMFHKVMQSYOBAV-KQVQOVSDNA-N
- 计算化学: 氢键受体数13.0氢键供体数9.0可旋转键数10.0
物理性质
- 熔点315-318 °C
- 沸点1117.1±65.0 °C at 760 mmHg
- 闪点629.4±34.3 °C
- 密度1.4±0.1 g/cm3
- pKa:12.85±0.70(预测)
- PSA:357.06
- LogP:4.73
- 折射率1.622
- 蒸汽压0.0±0.6 mmHg at 25°C
- 溶解性Chloroform (Very Slightly, Heated Sonicated), Pyridine (Slightly, Heated, Sonicated)
- 外观形态白色至类白色固体
- 储存条件防潮, -20°C 冰箱, 在惰性气其中
- 产品应用该化合物用作内容确定,识别和药理实验;展示强有力的抗血管和抗突扰活动.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Sun C, Gao W, Zhao B, Cheng L. Optimization of the selective preparation of 20(R)-ginsenoside Rg3 catalyzed by d, l-tartaric acid using response surface methodology. Fitoterapia. 2013 Jan;84:213-21. doi: 10.1016/j.fitote.2012.11.011. Epub 2012 Dec 3. Chinese. doi: 10.1016/j.jgr.2015.07.002. Epub 2015 Jul 29.
4: Yoon SJ, Park JY, Choi S, Lee JB, Jung H, Kim TD, Yoon SR, Choi I, Shim S, Park YJ. Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1184-9. doi: 10.1016/j.bbrc.2015.06.080. Epub 2015 Jun 15. Epub 2014 Jul 24. doi: 10.1111/1750-3841.12518. doi: 10.3892/mmr.2015.3802. Epub 2015 May 19. doi: 10.1155/2016/6967853. Epub 2016 Dec 26.
11: Yu X, Xu H, Hu M, Luan X, Wang K, Fu Y, Zhang D, Li J. Ginsenoside Rg3 bile salt-phosphatidylcholine-based mixed micelles: design, characterization, and evaluation. Chem Pharm Bull (Tokyo). 2015;63(5):361-8. doi: 10.1248/cpb.c15-00045. doi: 10.3892/mmr.2016.5349. Epub 2016 May 27.
合成参考文献
参考文献:10.1080/10286020.2011.588212
摘要:Weng X, Shao Y, Chen Y, Gao W, Cheng L, Kong D. Two new dammarane monodesmosides fromCentella asiatica. Journal of Asian Natural Products Research. 2011 Aug;13(8):749–55. doi: 10.1080/10286020.2011.588212.
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