📜4-Amidinopyridine Hydrochloride置于甲醇,Sodium体系中,化学反应 0.5H,反应生成 4-吡啶甲脒 参考文献:1H-Pyrimido[4,5-B]Indole Derivatives,Their Preparation And Therapeutic Use 标题:1H-Pyrimido[4,5-B]Indole Derivatives,Their Preparation And Therapeutic Use 摘要:这项发明涉及一般式(I)的化合物: 其中n,X,Y,R1和r2如本文所定义.该发明还涉及制备这些化合物以及它们的治疗用途的方法.
专利号:US-2004044225-A1 优先权日:2001-06-01 标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives 发明人:KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK 摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
专利号:US-6903227-B2 优先权日:2000-06-02 标题:Synthesis of 2-acyl substituted chromanes and intermediates thereof 发明人:KANTER JAMES; MULLINS JOHN J G; PANDEY ANJALI; SCARBOROUGH ROBERT 权利人:MILLENNIUM PHARM INC 摘要:Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.
专利号:US-6004965-A 优先权日:1994-12-20 标题 :Sulfonamides 发明人:BREU VOLKER; BURRI KASPAR; CASSAL JEAN-MARIE; CLOZEL MARTINE; HIRTH GEORGES; LOEFFLER BERND-MICHAEL; MUELLER MARCEL; NEIDHART WERNER; RAMUZ HENRI 权利人:HOFFMANN LA ROCHE 摘要:Compounds of the formula: ##STR1## where A, B, R 1 -R 8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions containing these compounds are also useful.
专利号:WO-2025217318-A1 优先权日:2024-04-09 标题:Kinetic controlled synthesis for 2d perovskite materials 发明人:MOHITE ADITYA; HOU JIN; AGRAWAL AYUSH 权利人:WILLIAM MARSH RICE UNIV 摘要:Methods of making a two-dimensional perovskite, a two-dimensional perovskite composition are disclosed. The two-dimensional perovskite comprises: a layered material having the formula (I) (A')(A)n-1MnX3n+1, where A' is an organic cation selected from the group consisting of butyl ammonium, 3-(aminomethyl)piperidium (3-AMP), 4- (aminomethyl)piperidium, and combinations thereof; A is a perovskitizer-cation selected from the group consisting of formamidinium (FA), guanidinium, dimethylamine, cesium, and combinations thereof; M is a divalent metal selected from the group consisting of Pb, Ge, Sn, Cu, and combinations thereof; X is a halide selected from the group consisting of I, Br, Cl, F, and combinations thereof; and n is greater than or equal to 2. The layered material comprises alternating layers of a first type and a second type, where the first type comprises the organic cation (A') and the second type comprises a hybrid anion having the formula (II) (A)n-1MnX3n+1, and the layered material has a tetragonal crystal structure with space group symmetry P4/mmm.
专利号:US-2003233002-A1 优先权日:2000-06-02 标 题:Synthesis of 2-Acyl substituted chromanes and intermediates thereof
专利号:WO-0192249-A2 优先权日:2000-06-02 标 题 :Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives