CAS: 291-64-5; Cycloheptane

该化合物是一种环烷,其分子式为C7H14,具有七人碳环的特性,是一种无色,易燃液体,在室内温度下呈现出一种独特的汽油味.Cycloheptane的沸点和熔点相对较大的环状甘蔗较低,反映其较小的环状尺寸.化合物是非极的,使其在水中溶解,但在诸如醚和苯等有机溶剂中溶解.其结构允许各种相容,其中最稳定的是椅子形式,以尽量减少胃紧张.Cycloptane用于有机合成和溶剂,并且作为研究环状菌株和循环碳氢化合物的再活性的一种模型化合物.此外,它可以发生典型的烷反应,例如燃烧和卤化.由于它的易燃性,在实验室或工业环境中处理环丙烷时,应当观察到适当的安全防范措施.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号628-92-2 环庚烯 | CAS号2404-35-5 溴代环庚烷 | CAS号100-58-3 苯基溴化镁 | CAS号591-51-5 苯基锂 | CAS号502-42-1 环庚酮 | CAS号876938-53-3 cyclohepta-1,3-diene | CAS号502-41-0 环庚醇 | CAS号2453-46-5 氯环庚烷 | CAS号100-59-4 苯基氯化镁 | CAS号544-25-2 环庚三烯 | CAS号402-43-7 对溴三氟甲苯 | CAS号502-41-0 环庚醇 | CAS号502-42-1 环庚酮 | CAS号1460-16-8 环庚烷羧酸 | CAS号2404-35-5 溴代环庚烷 | CAS号592-76-7 1-庚烯 | CAS号2004-70-8 反-1,3-戊二烯 | CAS号187737-37-7 propene | CAS号34557-54-5 methane

合成工艺路线路线简述

    环庚烯置于1-Thia-3,4-Diazolidine-2,5-Dione体系中,用 Various Solvent(S) 用作溶剂,以100%的收率获得环庚烷
    参考文献:通过光化学生成的二酰亚胺进行氢化
    标题:通过光化学生成的二酰亚胺进行氢化
    摘要:二酰亚胺是众所周知的用于以非常高的立体特异性氢化多个键的试剂.但是,所有产生二酰亚胺的方法都需要一定的严格条件.我们在这里显示1-Thia-3,4-Diazolidine-2,5-Dione(tdadh)可用于在室温,中性条件下光化学生产二酰亚胺.由此产生的二酰亚胺可以高产率氢化多个键.
    Doi:10.1016/s0040-4039(00)60511-7

    专利信息


    专利号:US-11926589-B2
    优先权日:2019-07-09
    标 题 :Process for the synthesis of non-racemic cyclohexenes
    发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND
    权利人:BASF CORP; CALIFORNIA INST OF TECHN
    摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.

    专利号:US-2008287649-A1
    优先权日:2006-12-29
    标 题 :Methods for the synthesis of cyclic peptides
    发明人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
    权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
    摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

    专利号:WO-2019170521-A1
    优先权日:2018-03-07
    标题 :Synthesis of obeticholic acid and synthesis intermediate
    发明人:BERNABEU MARTÃ?NEZ MARÃ?A DEL CARMEN; JIMÉNEZ ALONSO OSCAR; DOBARRO RODRÃ?GUEZ ALICIA; GABOARDI MAURO; CASTALDI GRAZIANO
    权利人:MOEHS IBERICA SL
    摘要:The present invention relates to a new intermediate for the synthesis of obeticholic acid, the compound of formula (I) or a geometric isomer thereof, a process for obtaining the same, as well as the use of said intermediate in the synthesis of obeticholic acid.

    专利号:US-2006287520-A1
    优先权日:2005-05-16
    标 题 :Synthesis of salinosporamide A and analogues thereof
    发明人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
    权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
    摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

    专利号:US-7094913-B2
    优先权日:2003-09-17
    标题:Synthesis of 7-membered carbocyclic compound having diexomethylene groups
    发明人:CHO YONG SEO; CHANG MOON HO; KOH HUN YEONG; PAE AE NIM; KANG HYUN JUNG
    权利人:KOREA INST SCI & TECH
    摘要:The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds. n n n n n n n n n n In Chemical Formula 1, R 1 is a C 1 to C 6 alkyl group, and R 2 and R 3 is respectively a hydrogen atom, or R 1 , R 2 and R 3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.

    专利号:US-7910623-B2
    优先权日:2005-07-22
    标 题 :Synthesis of scabronines and analogues thereof
    发明人:DANISHEFSKY SAMUEL J; WATERS STEPHEN P
    权利人:SLOAN KETTERING INST CANCER
    摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.
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    合成参考文献


    摘要:Zaidlewicz, M.; Krzemiński, M. P.; Dzieleńdziak, A., Science of Synthesis, (2009) 48, 359.
    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 242.
    摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 129.
    摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 210.
    摘要:Scott, P. J. H., Science of Synthesis Knowledge Updates, (2013) 4, 243.
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