CAS: 2713-34-0; 3,5-Difluorophenol

上下游产品

3,5-difluoroaniline 1,3,5-trifluorobenzene 3,5-difluoro-1-(diethoxymethylsilyl)benzene 3,5-difluorophenylboronic acid 3,5-Difluorophenoxyacetic acid 1-butoxy-3,5-difluorobenzene 3',5'-difluorophenyl 3,3-dimethylacrylate (S)-tert-butyl 2-(3,5-difluorophenoxymethyl)pyrrolidine-1-carboxylate

1-溴-3,5-二氟苯置于copper(L) Iodide,Sodium Hydroxide体系中,用 水 用作溶剂,以88 %的收率获得3,5-二氟苯酚
参考文献:一种氟代苯酚的工业化制备方法
标题:一种氟代苯酚的工业化制备方法
摘要:本发明公开了一种氟代苯酚的工业化制备方法,具体地,所述方法在碱性条件下,在铜/草酸二酰胺配体的催化作用下,(多)氟代卤代苯在加热条件下发生偶联反应,生成(多)氟代苯酚.本发明反应条件温和,无需高温高压,三废少,成本低,收率和纯度很高,易于工业化生产.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6689919-B1
优先权日:1999-09-22
标 题 :Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative
发明人：TSUCHIDA EISHUN; OYAIZU KENICHI; KUMAKI YOSUKE; SAITO KEI
权利人:JAPAN SCIENCE & TECH CORP
摘要:The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of -1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.

专利号:WO-2021143617-A1
优先权日:2020-01-16
标题 :Cyclohexadiene oxime ether compound, synthesis method therefor and application thereof
发明人：DENG ZHAOXI; Hu Hewei; GUO SHAOXIONG; CEN JIN; TAN BIN; DU BINGBING; YANG LINA; LI JUNPEI
权利人:ZHENGZHOU INSTITUTE OF CHIRAL DRUGS RES CO LTD
摘要:The present invention provides a cyclohexadiene oxime ether compound having the following structural formula: (I) or (II) or (III); group R 1 and group R 3 are each selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, and a halogenated aromatic substituent or a cyano-substituted aromatic substituent; group R 2 is selected from -H, an aliphatic substituent containing 1-6 carbon atoms, a halogenated aliphatic substituent, a cyano-substituted aliphatic substituent, amino or amide, phenyl, a halogenated aromatic substituent, and a cyano-substituted aromatic substituent, a nitro-substituted aromatic substituent or a heterocyclic aromatic substituent; and the heterocyclic aromatic substituent is selected from (iv), (v) or (vi), wherein X is selected from -H, halogen, -CN, -NO 2 , and -CF 3 , -C(CF 3 ) 3 , and n is the number of substituents and is selected from 1, 2, and 3. The present invention also provides a preparation method for the above-mentioned cyclohexadiene oxime ether compound and an application thereof.

专利号:US-7405310-B2
优先权日:2001-03-05
标 题:Non-nucleoside reverse transcriptase inhibitors
发明人：LINDSTROM STEFAN; SAHLBERG CHRISTER; WALLBERG HANS; KALYANOV GENAIDY; ODEN LOURDES SALVADOR; NAESLUND LOTTA
权利人:MEDIVIR AB
摘要:This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

专利号:US-6713435-B2
优先权日:2001-09-03
标 题:Method for producing optically active lactone compounds by using salen cobalt complexes having a cis-β structure
发明人：KATSUKI TSUTOMU; UCHIDA TATSUYA; ITO KATSUJI
权利人:UNIV KYUSHU
摘要:A method for producing an optically active lactone compound by Baeyer-Villiger oxidation of a cyclic ketone compound with at least one kind of oxidants selected from the group consisting of hydrogen peroxide and urine-hydrogen peroxide adduct (UHP) using a cobalt(salen) complex having a cis-β structure expressed by the following formula (I) or (II) as a catalyst. n in which X and Y independently denote H, a t-butyl group or an electron-withdrawing substituting group and W is a halogen element. n in which X and Y independently denote H, a t-butyl group or an electron-withdrawing substituting group and Z − is a monovalent anion. The optically active lactone compounds can be used for the synthesis of medicines and argochemicals.

专利号:EP-2687521-B1
优先权日:2012-07-20
标 题 :'Process for the enantioselective synthesis of landiolol'
发明人：GARAVAGLIA FABIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA