CAS: 23583-48-4; (4Ar,6R,7R,7As)-6-(6-Amino-8-Bromo-9H-Purin-9-yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine 2-Oxide
该化合物是生物化学和药理学研究中广泛使用的一种可膜透膜的CAMP模拟物,其8位置的溴替代会增强对磷化酶降解的抗药性,确保长期细胞内活性.该化合物有效地模仿了内生的CAMP,使它成为研究依赖CAMP信号路径,包括蛋白质动脉A(PKA)活化的宝贵工具. 8-Br-CAMP在细胞分析细胞差异,扩散和基因表达规范的细胞分析中特别有用.其稳定性和持续的生物活性提供了可靠的实验结果,支持了...
- 英文名称(4Ar,6R,7R,7As)-6-(6-Amino-8-Bromo-9H-Purin-9-yl)-2,7-Dihydroxytetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinine 2-Oxide
- 中文名称8-溴腺苷-3,5-环单磷酸
- IUPAC名称(4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
- 其它别名8-Br-Camp; 8-Bromoadenosine 3':5'-Cyclic Monophosphate; 8-Bromoadenosine-3',5'-Cyclic Monophosphate; 8-Bromoadenosine-3',5'-Cyclophosphate; 8-Bromoadenosine-3',5'-Cyclophosphoric Acid; 8-Bromo-Adenosine Cyclic 3',5'-Hydrogen Phosphate; 8-Bromo-Camp; 8-Bromoadenosine 3' 5'-Cyclic
- CAS编号23583-48-4
- MFCD编号:MFCD00075580
- EINECS号:245-760-6
- FDA UNII编号:5QO1UW05Q5
- 分子式:C10H11BrN5O6P分子量:408.11
- 产品CID: 1178128
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
60-92-4 41941-56-4 37839-81-9物理性质
MSDS等安全信息
上下游产品
CAS号60-92-4 环磷酸腺苷 | CAS号61363-29-9 8-(2-氨基乙基)氨基腺苷-...合成工艺路线路线简述
📜腺苷环磷酸酯置于溴,Sodium Acetate体系中,用 水 用作溶剂,化学反应 24.0H,以76%的收率获得8-溴腺苷3',5'-环单磷酸
参考文献:Stereoselective Preparation Of (Rp)-8-Hetaryladenosine-3',5'-Cyclic Phosphorothioic Acids
标题:Stereoselective Preparation Of (Rp)-8-Hetaryladenosine-3',5'-Cyclic Phosphorothioic Acids
摘要:在用草酰氯和 Dmf 原位生成的试剂活化磷酸分子之前,已将环磷酸腺苷(camp)转化为其 8-溴衍生物和 2â²o-Tbdms.与伯胺的进一步反应产生了相应的磷酰胺,磷原子具有很高的立体选择性.与 8-溴嘌呤的交叉耦合反应生成了 8-己二醛衍生物.X 射线分析表明,这些酰胺酸盐具有 (Sp) 构型.二硫化碳在强碱性条件下进行硫化反应,立体特异性地生成了 (Rp) 硫代磷酸.
Doi:10.1039/b702403G
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-9943814-A1
优先权日:1998-02-27
标 题 :Therapeutic blockade of icer synthesis to prevent icer-mediated inhibition of immune cell activity
发明人：COHEN PETER A; BODOR JOSEF; WENG DAVID E; KOSKI GARY K; CZERNIECKI BRIAN J; BODOROVA JANA
权利人:US HEALTH; COHEN PETER A; BODOR JOSEF; WENG DAVID E; KOSKI GARY K; CZERNIECKI BRIAN J; BODOROVA JANA
摘要:The present invention relates to reagents and methods for modulating immune cell activity using agents which regulate the activity of ICER.
专利号:US-2002065221-A1
优先权日:1995-12-20
标题:Control of protein synthesis, and screening method for agents
发明人：COHEN PHILIP; ALESSI DARIO; CROSS DARREN
摘要:A method for screening for agents capable of affecting the activity of kinases GSK3 and PKB is disclosed. The method involves assessing the phosphorylation of PKB on two amino acids on the PKB molecule particularly.
专利号:WO-9722360-A2
优先权日:1995-12-20
标题:Control of protein synthesis, and screening method for agents
专利号:EP-1056843-A1
优先权日:1998-02-27
标题:Therapeutic blockade of icer synthesis to prevent icer-mediated inhibition of immune cell activity
专利号:AU-1200497-A
优先权日:1995-12-20
标 题:Control of protein synthesis, and screening method for agents
专利号:DE-102006027450-A1
优先权日:2006-06-12
标 题:Method of inducing insulin synthesis in chorionic cells
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis And Enzymic And Ionotropic Activity Of Some New 8-Substituted And 6,8-Disubstituted Derivatives Of Adenosine Cyclic 3',5'-Monophosphate作者:Jon P. Miller,Kay H. Boswell,Rich B. Meyer,Leon F. Christensen,Roland K. Robins |发布日期:1980.3
摘要:The Synthesis Of Certain New 8-(Arythio)- And 8-(Alkylthio)-Camp Derivatives And N6-Alkyl- And N6-Dialkyl-8-(Arylthio) And -8-(Alkylthio) Derivatives Of Camp Is Reported. On The Basis Of Activation Of Protein Kinase, Several N6-Alkyl-8-(Benzylthio)-Camp Derivatives Were Selected For Evaluation As Inotropic Agents Using Cat Papillary Muscle In Vitro. Activity In These Studies Resulted In The Selection
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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