CAS: 2148-57-4; 4,7-Dichloroquinazoline

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7-氯-4(3H)-喹唑啉酮 7-Chloro-3,4-Dihydroquinazolin-4-One 31374-18-2

📜7-氯-4(3H)-喹唑啉酮置于氯化亚砜体系中,化学反应生成4,7-二氯喹唑啉
参考文献:通过基于结构的方法发现新型登革热病毒进入抑制剂
标题:通过基于结构的方法发现新型登革热病毒进入抑制剂
摘要:登革热是一种由蚊子传播的病毒,近年来已成为全球主要的公共卫生问题.但是,目前对登革热疾病的治疗仅是支持性治疗,尚无特异性抗病毒药可用于控制感染.因此,最需要安全有效的抗病毒药物.登革热病毒(denv)进入宿主细胞的过程是由其主要包膜蛋白e介导的.E蛋白的晶体结构揭示了位于结构域i和ii之间铰链区的去污剂n-辛基-β-D-葡萄糖苷(β-Og)占据的疏水口袋,这对于低ph触发很重要融合所需的构象重排.因此,E蛋白是开发抗病毒剂的有吸引力的靶标.在这项工作中,我们进行了基于前期对接的虚拟筛选,以鉴定可能与β-Og结合位点结合的小分子.鉴定出了23种结构上不同的化合物,其中两个在低微摩尔范围内的ec 50值.特别地,化合物2(ec 50 = 3.1μm)显示出显着的抗病毒活性并具有非常好的治疗指数.使用分子动力学模拟来尝试表征2与蛋白质e的相互作用,从而为将来的配体优化工作铺平了道路.这些研究突
Doi:10.1016/j.Bmcl.2017.06.049

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:CA-2611219-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:KR-20080033234-A
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis