CAS: 174800-02-3; Fmoc-Hyp(Bzl)-Oh
该化合物是羟丙酮的衍生物,氨酸是一种对蛋白结构和稳定性具有关键作用的氨基酸;该化合物具有9-氟甲基苯氧碳酸(Fmoc)保护组,在混合过程中,该组通常用于浸泡合成中,以保护氨基组;氢氧丙酸副链中含有苯基(Bzl)组,这加强了分子的疏水特性,可影响其溶性以及与其他生物分子的相互作用;氟化硫-氢(BZl)-OH通常用于固相聚,在温和条件下可有选择地去除其保护组以促进形成peptide联结;该复合的特点是其在标准实验室条件下保持稳定,其活性主要受现有功能组的支配;总体而言,Fmoco-Hyp(Bsl) -HeHym是化学和生物化学领域浸泡剂和其他复杂有机分子合成中的宝贵建筑块.
- 英文名称Fmoc-Hyp(Bzl)-Oh
- 中文名称N-芴甲氧羰基-O-苄基-L-4-羟基脯氨酸
- IUPAC名称(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(benzyloxy)pyrrolidine-2-carboxylic acid
- 其它别名Fmoc-O-苄基-L-4-羟基脯氨酸; (2S,4R)-1-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)-4-(Benzyloxy)Pyrrolidine-2-Carboxylic Acid
- CAS编号174800-02-3
- MFCD编号:MFCD00237023
- EINECS号:191-183-7
- 分子式:C27H25NO5分子量:443.5
- 产品CID: 892246
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号100-39-0 溴化苄 | CAS号13726-69-7 B°C-L-羟脯氨酸 | CAS号40350-83-2 4-(Benzyloxy)-1... | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号40350-84-3 (2S,4R)-4-(benz...合成工艺路线路线简述
📜Boc-L-羟脯氨酸置于盐酸,Sodium Hydride,碳酸氢钠,Sodium Iodide体系中,用 四氢呋喃,1,4-二氧六环,丙酮 用作溶剂,化学反应生成Fmoc-O-苄基-L-4-羟基脯氨酸
参考文献:Capped Dipeptide Phenethylamide Inhibitors Of The Hcv Ns3 Protease
标题:Capped Dipeptide Phenethylamide Inhibitors Of The Hcv Ns3 Protease
摘要:The N-Terminal Aminoacid Of Phenethylamide Tripeptide Inhibitors Of The Hepatitis C Virus Ns3 Protease Can Be Replaced With An A-Hydroxy Acid To Obtain More 'Drug Like' Inhibitors With Low Micromolar Activity. The Preferred S-Configuration Of The Capping Residue Can Be Explained By Molecular Modeling Studies. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2004.02.032
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905399002-1,4-丁二醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
