CAS: 168960-19-8; ((1S,4R)-4-Aminocyclopent-2-En-1-yl)Methanol Hydrochloride

相似化合物

229613-83-6 136522-35-5 287717-44-6

2-氮杂双环[2.2.1]庚-5-烯-3-酮置于盐酸,三乙基硼氢化锂体系中,用 四氢呋喃,甲醇,水 用作溶剂,化学反应 2.5H,反应生成(1S,4R)-(4-氨基环戊-2-烯基)甲醇盐酸盐
参考文献:Carbocyclic Sugar Amines: Synthesis And Stereochemistry Of Racemic .Alpha.-And .Beta.-Carbocyclic Ribofuranosylamine,Carbocyclic Lyxofuranosylamine,And Related Compounds
标题:Carbocyclic Sugar Amines: Synthesis And Stereochemistry Of Racemic .Alpha.-And .Beta.-Carbocyclic Ribofuranosylamine,Carbocyclic Lyxofuranosylamine,And Related Compounds
摘要:
Doi:10.1021/jo00329A026

专利信息

专利号:US-7358073-B2
优先权日:1997-11-27
标题:Process for the preparation of aminoalcohol derivatives and their further conversion to (1R, 4S)-4(2-amino-6-chloro-5-formamido-4- pyrimidinyl)-amino-2-cyclopentenyl-1-methanol
发明人：BRIEDEN WALTER; SCHROER JOSEF; BERNEGGER-EGLI CHRISTINE; URBAN EVA MARIA; PETERSEN MICHAEL; RODUIT JEAN-PAUL; BERCHTOLD KATJA; BREITBACH HOLGER
权利人:LONZA AG
摘要:The invention relates to a novel process for the preparation of an aminoalcohol of the formula n nracemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9-H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulaen n nIn the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl) formamide of the formulan n nto give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulaen n nand then cyclized to give the end compounds.

专利号:CN-104974051-A
优先权日:2015-06-30
标 题:Synthesis of (1S,4R)-cis-4-amino-2-cyclopentene-1-methanol hydrochloride