CAS: 16139-18-7; Hydrazinecarboximidamide Hydrochloride(1:X)

上下游产品

ethanol CYANAMID aminoguanidine bicarbonate acetic acid 2-guanylhydrazide hydr°Chlorideisonicotinic acid 2-amidinohydrazide bis(5-amino-1,2,4-triazol-3-yl)methane phenacylidenamino-guanidine 3-amino-6-phenyl-1,2,4-triazine

📜氨基胍碳酸氢盐置于盐酸体系中,用 乙醇 用作溶剂,化学反应生成肼甲酰亚胺酰胺一氯化氢
参考文献:由6-(2,4-二氯-5-硝基苯基)咪唑并[2,1-B]噻唑和6-吡啶并咪唑并[2,1-B]噻唑(1)合成胍基hydr并具有抗肿瘤活性.
标题:由6-(2,4-二氯-5-硝基苯基)咪唑并[2,1-B]噻唑和6-吡啶并咪唑并[2,1-B]噻唑(1)合成胍基hydr并具有抗肿瘤活性.
摘要:报道了抗肿瘤咪唑并噻唑胍基hydr的设计与合成.这些化合物已提交给nci进行测试.除了一个以外,所有的活性都比甲基-Gag高.选择了几种化合物进行进一步的研究,以寻找可能的作用机理.这些研究的结果以及使用nci Compare算法进行的最终搜索表明,本文所述的胍基hydr酮是通过一种新的作用机理起作用的.
Doi:10.1021/jm061077M

专利信息

专利号:WO-2025078505-A1
优先权日:2023-10-13
标 题 :One pot gmp scalable production method for the synthesis of dextran-guanidine-bisphosphonate conjugate
发明人：HOLMBERG ANDERS R
权利人:DEXTECH MEDICAL AB
摘要:The disclosure relates to a large scale GMP synthesis of a modified dextran conjugate, and more particularly to a dextran-guanidine-bisphosphonate conjugate wherein the bisphosphonate is an alendronate group. The disclosure relates to a large scale GMP synthesis that produces high purity, pharmaceutical grade dextran-guanidine-bisphosphonate conjugate. The present disclosure further concerns the use of said dextran-guanidine-bisphosphonate conjugate in medicines treating tumors.

专利号:US-12108759-B2
优先权日:2018-11-04
标 题:Synthesis of antimicrobial carbon dots and uses thereof
发明人：JELINEK RAZ; BHATTACHARYA SAGARIKA; OTIS GIL
权利人:B G NEGEV TECHNOLOGIES & APPLICATIONS LTD AT BEN GURION UNIV
摘要:The present invention relates to antibacterial carbon dots, having aminoguanidine functionality on their outermost surface. The invention further relates to the synthesis of said antibacterial carbon dots, and to the uses of these carbon dots for inhibiting a biofilm formation in the presence of said carbon dots and as fluorescent labeling markers for specific bacteria.

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-9296709-B2
优先权日:2012-07-03
标 题 :Manufacture of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid
发明人：GUNIC ESMIR; GALVIN GABRIEL
权利人:ARDEA BIOSCIENCES INC
摘要:Described herein are certain processes for the synthesis of compounds of Formula (I):

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:WO-2024141087-A1
优先权日:2022-12-31
标 题:In-vitro cell-free protein synthesis system for inserting non-natural amino acid, and method and use
发明人：GUO MIN; ZHENG LI; XU LIQIONG; FANG PENGFEI; YU XUE
权利人:KANGMA HEATHCODE SHANGHAI BIOTECH CO LTD
摘要:Provided is an in-vitro cell-free protein synthesis system for inserting a non-natural amino acid. The reaction system comprises: (1) a yeast cell extracting solution; (2) a non-natural amino acid; (3) an exogenous orthogonal aminoacyl tRNA synthetase/orthogonal tRNA pair; and (4) a template containing a target protein gene sequence, wherein at least one codon encoding an amino acid in the target protein gene sequence is mutated into a stop codon. By means of the reaction system, the insertion efficiency of the non-natural amino acid and the expression quantity of the non-natural amino acid protein can be increased.