CAS: 157431-09-9; (R)-2-(Dimethylamino)Propanoic Acid

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CAS号50-00-0 甲醛 | CAS号338-69-2 D-丙氨酸

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    📜D-丙氨酸 反应生成N,N-二甲基-D-丙氨酸
    参考文献:The Absolute Configurations Of The α-And β-Methylcholine Isomers And Their Acetyl And Succinyl Esters
    标题:The Absolute Configurations Of The α-And β-Methylcholine Isomers And Their Acetyl And Succinyl Esters
    摘要:摘要:已确定(+)-乙酰-α-和-β-甲基胆碱碘化物的绝对构型,分别与d(-)-丙氨酸盐酸盐和l(+)-乳酸相关.这些前体氨基醇的(+)-,(-)-和外消旋形式已被转化为琥珀酰酯,并进行了季铵化处理.
    Doi:10.1111/j.2042-7158.1963.Tb12798.X

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    专利信息


    专利号:US-10040752-B2
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
    发明人:MKRTCHYAN GNEL; YAO QINGWEI
    权利人:CODY LABORATORIES INC
    摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

    专利号:US-2019002394-A1
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

    专利号:US-2017057909-A1
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

    专利号:EP-3341354-A1
    优先权日:2015-08-24
    标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

    专利号:US-2020277250-A1
    优先权日:2019-04-17
    标 题 :Synthesis of levomethadone hydrochloride

    专利号:WO-2017035224-A1
    优先权日:2015-08-24
    标 题:Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Total Synthesis And Biological Evaluation Of Tubulysin U, Tubulysin V, And Their Analogues
    作者:Ranganathan Balasubramanian,Bhooma Raghavan,Adrian Begaye,Dan L. Sackett,Robert A. Fecik |发布日期:2009.1.22
    摘要:A Stereoselective Total Synthesis Of The Cytotoxic Natural Products Tubulysin U, Tubulysin V, And Its Unnatural Epimer Epi-Tubulysin V, Is Reported. Simplified Analogues Containing N,N-Dimethyl-D-Alanine As A Replacement For The N-Terminal N-Me-Pipecolinic Acid Residue Of The Tubulysins Are Also Disclosed. Biological Evaluation Of These Natural Products And Analogues Provided Key Information With Regard
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