CAS: 153254-09-2; 2,4-Bis(Trifluoromethyl)Phenylboronic Acid

相似化合物

1021860-94-5 681812-07-7 1423-27-4

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号327-75-3 2,4-二(三氟甲基)溴苯

📜硼酸三甲酯,间二三氟甲苯置于2,2,6,6-Tetramethylpiperidinyl-Lithium体系中,化学反应 5.0H,以70.6%的收率获得2,4-双三氟甲基苯硼酸
参考文献:一种合成2,4-二三氟甲基苯硼酸的方法
标题:一种合成2,4-二三氟甲基苯硼酸的方法
摘要:本发明属于药物化合物的合成领域.一种合成2,4‑二三氟甲基苯硼酸的方法,第一步合成中间体:将2,2,6,6‑四甲基哌啶与正丁基锂在溶剂中反应得中间体;第二步硼化反应:将中间体a与1,3‑二三氟甲苯反应拔氢,然后与硼酸酯反应硼化,酸化生成2,4‑二三氟甲基苯硼酸.本发明两步总收率70%以上,本发明方法原料易得,操作简便,是一种制备2,4‑二三氟甲基苯硼酸的适宜工业化路径.

专利信息

专利号:US-5491167-A
优先权日:1993-01-29
标题 :Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses
发明人：ISHIHARA SADAO; KOGEN HIROSHI; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA
权利人:SANKYO CO
摘要:Compounds of formula (I): ##STR1## and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-113264949-A
优先权日:2021-05-31
标 题 :Design, Synthesis and Application of a Class of Spirobenzoxazine Piperidine α,β-Unsaturated Ketone Derivatives