CAS: 146137-78-2; 2-Fluoro-5-(Trifluoromethyl)Benzaldehyde

相似化合物

115029-23-7 207974-09-2 4088-84-0

上下游产品

4-Fluorobenzotrifluoride N,N-dimethyl-formamide 2-fluoro-5-trifluoromethyl-benzonitrile methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 2-amino-6-trifluoromethylquinazoline 3-(4-chloro-3-ethylphenoxy)-N-[2-fluoro-5-(trifuoromethyl)benzyl]aniline

2-氰基-1-氟-4-(三氟甲基)苯置于aluminum Nickel 甲酸体系中,用 水 用作溶剂,化学反应生成2-氟-5-(三氟甲基)苯甲醛
参考文献:3,4-Dihydro-4-Oxo-3-(2-Propenyl)-1-Phthalazineacetic Acids And
标题:3,4-Dihydro-4-Oxo-3-(2-Propenyl)-1-Phthalazineacetic Acids And
摘要:新颖的3,4-二氢-4-氧基-3(丙-2-烯基)-1-邻苯二甲酸和式(I)的衍生物##str1##其中r.Sub.1,R.Sub.2和r.Sub.3相同或不同,代表h,卤素或线性或支链脂肪饱和或不饱和基团,该基团至少被一个卤素或r.Sub.4残基取代,R.Sub.4不为h时,除非r.Sub.4为h;R.Sub.4和r.Sub.5相同或不同,代表h,线性或支链脂肪基团,饱和或不饱和基团,芳基或杂环芳基,这些基团至少被氟,氯,溴,甲基或三氟甲基等基团取代或不取代,其中r.Sub.4和r.Sub.5不同时代表h;R.Sub.6代表羟基或烷氧基基团;R.Sub.7代表h,卤素,线性或支链脂肪饱和或不饱和基团,烷氧基基团,该基团被脂肪基或卤素基团取代或不取代,硝基基团,取代或未取代的氨基基团,S(O)Nr.Sub.8或氰基团;N等于0,1或2;R.Sub.8是线性或支链脂肪基团,芳基或杂环芳基,氨基基团,这些基团被脂肪基或卤素基团取代或不取代.本发明还涉及所述酸的可选互变异构体形式及其药学上可接受的碱盐.还描述了制备所述化合物和含有相同化合物的药物的方法.

专利信息

专利号:US-9446047-B2
优先权日:2013-09-10
标 题 :Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ. The compounds of the present invention are useful for modulating RORγt)/RORγ activity and for treating diseases or conditions mediated by RORγt)/RORγ such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.