CAS: 130752-32-8; Fmoc-D-Arg-Oh

该化合物是一种受保护的氨酸D-arginine,通常用于peptide合成.Fmoc组是一种保护性动物,在合成过程中可以有选择性地取消保护.该组具有基本的侧链,因为它在正辛酸中存在促进极地溶剂溶解的,该组在表面上一般白色,在标准实验室条件下稳定.Fmoc-D-Arg-OH,它存在于二甲基二甲基二苯丙胺和二甲基硫氧化二甲基硫酸等有机溶剂中,但水中的溶解度较少.该化合物用于合成peptid和蛋白质,特别是在固相聚聚物合成中,在基本条件下可以很容易去除Fmoc组.在生物化学研究和药物开发中具有价值,在设计生物活性化学剂时,应作为所有化学剂的防范剂.

英文名称Fmoc-D-Arg-Oh
中文名称N-α-Fmoc-D-精氨酸
IUPAC名称(((9H-fluoren-9-yl)methoxy)carbonyl)-D-arginine
其它别名Fmoc-D-精氨酸; Fmoc-D-Arg-Oh
CAS编号130752-32-8
MFCD编号:MFCD00077047
分子式:C21H24N4O4分子量:396.44
产品CID: 466858
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DVBUCBXGDWWXNY-GOSISDBHSA-N
InChI=1S/C21H24N4O4/c22-20(23)24-11-5-10-18(19(26)27)25-21(28)29-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17-18H,5,10-12H2,(H,25,28)(H,26,27)(H4,22,23,24)/t18-
计算化学: 氢键受体数4.0氢键供体数5.0可旋转键数8.0

相似化合物

1119-34-2 114622-81-0 1159-15-5

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明H303+H313+H333

上下游产品

Nα-(9-fluorenylmethoxycarbonyl)-Nγ-(4-methoxy-2,3,6-trimethylbenzenesulphonyl)-L-arginine α-9-Fluorenylmethyloxycarbonyl-NG-2,4,6-triisopropylbenzenesulphonyl-L-arginineNα-9-Fluorenylmethyloxycarbonyl-NG-2,4,6-triisopropylbenzenesulphonyl-L-arginine α-9-Fluorenylmethyloxycarbonyl-NG-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginineNα-9-Fluorenylmethyloxycarbonyl-NG-4-methoxy-3,5-di-tert-butylbenzenesulphonyl-L-arginine α-9-fluorenylmethyloxycarbonyl-NG-biphenyl-4-sulphonyl-L-arginineNα-9-fluorenylmethyloxycarbonyl-NG-biphenyl-4-sulphonyl-L-arginine

合成工艺路线路线简述

📜N'-[(2,3-二氢-2,2,4,6,7-五甲基苯并呋喃-5-基)磺酰基]-N-芴甲氧羰基-D-精氨酸置于三氟乙酸体系中,用乙腈用作溶剂,化学反应 0.33H,反应生成Fmoc-D-精氨酸
参考文献:Pressurized Sample Infusion: An Easily Calibrated,Low Volume Pumping System For Esi-Ms Analysis Of Reactions
标题:Pressurized Sample Infusion: An Easily Calibrated,Low Volume Pumping System For Esi-Ms Analysis Of Reactions
摘要:Pressurized Sample Infusion (Psi) Continuously Delivers Solution From A Flask Through Capillary Tubing At A Flow Rate That Makes It Suitable As A Low Internal Volume Pumping Method For Electrospray Ionization Mass Spectrometry (Esi-Ms). The Flow Rate Can Be Predicted From The Applied Pressure By Using The Hagen-Poiseuille Equation,But Variability In Internal Diameter Of The Peek Tubing Used Is Such That Each Individual Length Should Be Calibrated If Accurate Results Are Sought. Once Calibrated,The Values Hold Well For Different Solvents Across A Range Of Pressures. The Technique Has Been Exemplified In Two Reactions: The Deprotection Of A Protected Amino Acid Using Trifluoroacetic Acid,And In The Platinum-Catalyzed Redistribution Of Two Silanes. In Both Cases,The Abundances Of Starting Material,Product(S) And Intermediates Were Tracked In Real Time As The Reaction Proceeded. (C) 2012 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Ijms.2012.03.007