CAS: 1196-69-6; Indole-5-Carboxaldehyde

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CAS号16066-91-4 5-碘吲哚 | CAS号201230-82-2 carbon monoxide | CAS号1075-25-8 吲哚-5-甲醇 | CAS号1670-81-1 吲哚-5-羧酸 | CAS号10075-50-0 5-溴吲哚 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1313-13-9 二氧化锰 | CAS号594-19-4 叔丁基锂 | CAS号944893-74-7 1-乙基-1H-吲哚-5-甲醛 | CAS号90923-75-4 1-甲基-1H-吲哚-5-甲醛 | CAS号21005-48-1 5-(2-nitroethen... | CAS号63263-88-7 1-苄基吲哚-5-甲醛 | CAS号1075-25-8 吲哚-5-甲醇 | CAS号166670-56-0 2-(1H-indol-5-y... | CAS号279256-09-6 5-甲酰基-1H-吲哚-1-羧酸叔丁酯 | CAS号15861-24-2 5-氰基吲哚 | CAS号77132-99-1 5-ethenyl-1H-indole | CAS号671215-62-6 1-PHENYLSULFONY...

吲哚-5-羧酸 反应生成5-吲哚甲醛
参考文献:新型固相weinreb酰胺促进了醛和酮的平行合成.
标题:新型固相weinreb酰胺促进了醛和酮的平行合成.
摘要:本文介绍了一种新型的负载型weinreb酰胺树脂,该树脂有助于以可用于化学库合成的规模并行合成醛和酮.这种新的树脂可以从多种羧酸(包括n-Boc-氨基酸)生产定制的醛和酮.可以轻松地并行合成各种商业上不可用的醛,并通过简单的过滤后处理以高纯度获得这些醛,从而促进了铅优化库的并行合成,该库通常需要定制醛中间体的合成来发展结构-活性关系.为了证明此方法的实用性,我们基于支持的horner-Emmons试剂合成了一个小型文库.这是首次证明通过担载的weinreb酰胺产生的醛可直接用作采用对水分敏感的反应的化学文库合成中的试剂.由于必需的费力的萃取后处理程序,有时这些反应性中间体的不稳定性,因此类似的溶液反应不适合于平行合成.
Doi:10.1021/jo981431R

专利信息

专利号:EP-1572647-A2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof

专利号:WO-2004056769-A2
优先权日:2002-12-20
标 题:Synthesis of amines and intermediates for the synthesis thereof

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:US-9926293-B2
优先权日:2014-05-30
标题 :Multivalent RAS binding compounds
发明人：STOCKWELL BRENT R; WELSCH MATTHEW
权利人:UNIV COLUMBIA
摘要:The present invention provides, inter alia, compounds having the structure: n nwherein R 7 , R 8 and n are as disclosed herein, that selectively bind a RAS protein at two or more sites and methods for their synthesis. Compositions and kits containing the compounds, as well as methods of using the compounds and compositions for ameliorating or treating the effects of a disease associated with altered RAS signaling, such as a cancer, in a subject and methods for effecting cancer cell death are also provided herein. Methods of identifying a multivalent compound which binds selectively to a target protein also are provided herein.