CAS: 11141-16-5; Pcb 1

专利信息

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-4565896-A
优先权日:1984-10-22
标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas
发明人：KNIFTON JOHN F; DURANLEAU ROGER G
权利人:TEXACO INC
摘要:This invention relates to the manufacture of ethylene glcyol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus formaldehyde in the presence of a homogeneous liquid catalyst containing an effective amount of cobalt-containing compound and a silicon or germanium-containing promoter and a solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi wherein said ethylene glycol product separates as a separate liquid phase from the solvent.

专利号:US-4568780-A
优先权日:1984-10-22
标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas plus 1,3-dioxolane
发明人：KNIFTON JOHN F
权利人:TEXACO INC
摘要:This invention relates to the manufacture of ethylene glycol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus 1,3-dioxolane in the presence of a homogenous liquid catalyst containing an effective amount of cobalt-containing compound and a silane or germane-containing promoter dispersed in a hydrocarbon solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi, where the particular solvents used allow the desired product to be separated from the reaction mixture by phase separation.

专利号:US-7408085-B2
优先权日:2006-11-28
标 题:Rapid cost effective method for the synthesis of TPD-type arylamines
发明人：BENDER TIMOTHY P; COGGAN JENNIFER A; MCGUIRE GREGORY; MURPHY LEANNE DAWN; TOTH ALAN EDWARD JOHN
权利人:XEROX CORP
摘要:A process for forming a tetra(aryl)-biphenyldiamine compound, including reacting a dibromobiphenyl compound and a diarylamine compound in the presence of a palladium ligated catalyst and a base.

专利号:US-7402700-B2
优先权日:2006-11-28
标题 :Rapid, cost effective method for synthesis of diarylamine compounds
发明人：BENDER TIMOTHY P; COGGAN JENNIFER A
权利人:XEROX CORP
摘要:A process for forming a diarylamine compound, including reacting an aniline and an arylbromide in the presence of a palladium ligated catalyst and a base.

专利号:US-7345203-B1
优先权日:2006-11-28
标题:Cost effective method for synthesis of triarylamine compounds from an aniline and an arylchloride
发明人：BENDER TIMOTHY P; COGGAN JENNIFER A
权利人:XEROX CORP
摘要:A process for forming a triarylamine compound, including reacting an aniline and an arylchloride in the presence of a ligated palladium catalyst and a base.