CAS: 1112-37-4; 1-[chloro(Ethyl)Phosphoryl]Ethane

该化合物是一种有机磷化合物,广泛用作有机合成中的关键中间体,其反应式磷化物组能够有效地将二乙基磷酰胺纳入目标分子,使其对建造磷酸盐,磷氧化物和其他含磷衍生物具有价值;该化合物表现出对核素的高度反应性,有利于在制药,农用化学品和离心合成方面的应用;在受控条件下的稳定性确保了在无水环境中的可靠处理;二乙基磷基氯化物特别有利于精确地引入磷基功能组,支持催化和材料科学的进步;建议在惰性大气中适当储存以保持其完整性.

英文名称1-[chloro(Ethyl)Phosphoryl]Ethane
中文名称二乙基氯化膦
IUPAC名称1-[chloro(ethyl)phosphoryl]ethane
其它别名Chlorodiethylphosphineoxide; Diethylphosphinic chloride; Diethylphosphinyl chloride
CAS编号1112-37-4
MFCD编号:MFCD00013903
EINECS号:679-010-8
分子式:C4H10ClOP
分子量:140.55
产品CID: 148994
产品分类有机原料 → 有机膦化合物

相似结构搜索
产品信息参考;;;;
InChIKey: KGENPKAWPRUNIG-UHFFFAOYSA-N
InChI=1S/C4H10ClOP/c1-3-7(5,6)4-2/h3-4H2,1-2H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
防范说明P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a
危险等级8
UN编号3265
危险品标志C
包装等级II
安全声明26-36/37/39
危险类别码34-36/37/38

欧盟法规

C&L通报

上下游产品

diethylphosphinic acid Ethyl diethylphosphinite tetrachloromethane Diethylphosphinep-nitrophenyl diethylphosphinate p-tolyl esterdiethyl-phosphinic acid p-tolyl ester diethylphosphinic acid-(phosphoric acid diethyl ester)-anhydride diethyl-phosphinic acid phenethyl ester

合成工艺路线路线简述

合成目标产物 Diethylphosphinic Chloride 主要起始原料 Diethylphosphinic Acid
(文献来源)合成步骤主要原料 Diethylphosphinic Acid

氯化二乙基磷置于五氯化磷,溴体系中,化学反应生成二乙基氯化膦
参考文献:Halmann,M.,Phosphorus And Sulfur And The Related Elements,1988,Vol. 40,P. 251-262
标题:Halmann,M.,Phosphorus And Sulfur And The Related Elements,1988,Vol. 40,P. 251-262

海关参考信息

2901100000-饱和无环烃
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专利信息

专利号:WO-2009054887-A1
优先权日:2007-10-22
标题:Process for preparing an anti-hypercholesterolemic compound
发明人：LIMANTO JOHN; TAN LUSHI; DREHER SPENCER D; DORNER BENJAMIN T; YOSHIKAWA NAOKI; KRSKA SHANE W
权利人:MERCK & CO INC; LIMANTO JOHN; TAN LUSHI; DREHER SPENCER D; DORNER BENJAMIN T; YOSHIKAWA NAOKI; KRSKA SHANE W
摘要:The present invention relates to a process for preparing inhibitors of cholesterol absorption of Formula II: II and the pharmaceutically acceptable salts and esters thereof, employing a metal-catalyzed dynamic kinetic resolution (DKR) asymmetric transfer hydrogenation (ATH) reaction of racemic acyclic ÃŸ-ketoamide bearing a-substituted aliphatic side chain (Intermediate A) and subsequent cyclization of the resulting b-hydroxyamide product (Intermediate B), followed by a synthesis involving two consecutive cross-coupling reactions.