CAS: 105496-31-9; Fmoc-Glycinol

该化合物是一种化学化合物,其特点是存在一种与乙醇胺协会附属的氟乙烯-九-甲基碳基(Fmoc)保护组,该化合物经常用于有机合成,特别是浸泡化学,作为氨基功能的保护组,该化合物在基本条件下因其稳定性而闻名,可以在温酸条件下被清除,从而有利于连续合成过程.N-Fmoc-乙醇胺一般是白色的,白色的,脱白的固体,在二氯甲烷和二甲基硫胺等有机溶剂中可溶解,但水中可溶性较少.该化合物的分子结构包括一个矿物质功能组,有助于其再活动并形成氢结的能力.该化合物还被用于开发各种药剂和制作机能化材料.应当与所有化学物质一样,参考安全数据,以确保实验室环境中的妥善处理和使用.

结构式图片

相似化合物

101-98-4 104-63-2 26690-80-2

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上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号141-43-5 2-氨基乙醇 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号29022-11-5 Fm°C-甘氨酸 | CAS号2002-24-6 盐酸乙醇胺 | CAS号156939-62-7 N-芴甲氧羰基甘氨醛

合成工艺路线路线简述

    📜Fmoc-甘氨酸置于三聚氯氰,Potassium Carbonate,三苯基膦,Sodium Tetrahydroborate体系中,用 Neat (No Solvent) 用作溶剂,化学反应 0.25H,以87%的收率获得2-(N-芴甲氧羰基氨基)乙醇
    参考文献:无溶剂还原羧酸到用nabh醇4由2,4,6-三氯-1,3,5-三嗪和pph促进3中k的存在2 Co 3 †
    标题:无溶剂还原羧酸到用nabh醇4由2,4,6-三氯-1,3,5-三嗪和pph促进3中k的存在2 Co 3 †
    摘要:开发了一种简单,快速且环保的方法,将2,4,6-三氯-1,3,5-三嗪(tct)与一种无溶剂的nabh 4在无溶剂条件下将羧酸还原为醇催化量的三苯膦作为酸活化剂.在tct:Pph 3 :K 2 Co 3 :Nabh 4的摩尔比为1:0.2:1.5:2的情况下,包括芳族酸,脂族酸和n-保护的α-氨基酸(fm°C,Z)的羧酸很容易经历还原,在10分钟内得到相应的醇,收率非常好.
    Doi:10.1039/c4Ra08643K

    海关参考信息

    专利信息


    专利号:US-9206222-B2
    优先权日:2009-06-29
    标题:Solid phase peptide synthesis of peptide alcohols
    发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
    权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
    摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

    专利号:US-5902878-A
    优先权日:1989-05-24
    标 题 :Modified phosphoramidite process for the production of modified nucleic acids
    发明人：SELIGER HEINZ-HARTMUT; BERNER SIBYLLE; MUEHLEGGER KLAUS; VON DER ELTZ HERBERT; BATZ HANS-GEORG
    权利人:BOEHRINGER MANNHEIM GMBH
    摘要:The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

    专利号:US-5783674-A
    优先权日:1989-02-17
    标 题 :Method for the use and synthesis of peptides
    发明人：GEYSEN HENDRIK MARIO
    权利人:CHIRON CORP
    摘要:A method for the separation of at least one specific binding entity from a mixture of binding entities by the steps of contacting a mixture of binding entities with immobilized peptides in which the peptides specifically bind to the specific binding entities and the peptides contain an amino acid which facilitates removal of the binding entities from the peptides, and separating the immobilized peptide/specific binding entity complexes from the mixture of binding entities. A change in incubation conditions facilitates removal of the binding entities from the immobilized peptides.

    专利号:US-6147159-A
    优先权日:1998-09-30
    标 题 :Compositions for organic synthesis on solid phase and methods of using the same
    发明人：HU YONGHAN; LABADIE JEFFREY W; PORCO JR JOHN ANTHONY; TROST BARRY MARTIN
    权利人:ARGONAUT TECHNOLOGIES
    摘要:A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having the general formula: wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.

    专利号:US-2012108748-A1
    优先权日:2009-06-29
    标 题:Solid phase peptide synthesis of peptide alcohols

    专利号:EP-0458841-A1
    优先权日:1989-02-17
    标 题:METHOD FOR THE USE AND SYNTHESIS OF PEPTIDES.

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    合成参考文献


    摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 78.
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