CAS: 102185-34-2; Boc-D-Pro-Osu

相似化合物

3397-33-9 109074-94-4 30189-36-7

上下游产品

CAS号344-25-2 D-脯氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号37784-17-1 B°C-D-脯氨酸

D-脯氨酸置于n,N'-二环己基碳二亚胺体系中,用 乙醇,乙腈 用作溶剂,化学反应 0.17H,反应生成Boc-D-脯氨酸羟基琥珀酰亚胺硬脂酸酯
参考文献:嵌入亲和素中的催化阴离子:手性和手性环境对醛醇缩合反应立体控制的重要性
标题:嵌入亲和素中的催化阴离子:手性和手性环境对醛醇缩合反应立体控制的重要性
摘要:制备了带有伪二肽支架的几种催化阴离子,并结合了生物素化的咪唑鎓阳离子.这些盐与抗生物素蛋白的组装导致形成稳定的生物杂交催化剂,该催化剂在离子液体/水性介质中对醛醇缩合反应具有活性.通过使用天然和非天然氨基醇作为脯氨酸衍生物阴离子的"侧链",我们研究了阴离子与其在亲和素中的位置之间的协同作用.利用阴离子在抗生物素蛋白内部的较大移动自由度,我们还研究了这种类型的生物杂交催化剂的底物范围.
Doi:10.1021/jo5002406

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.