CAS: 904814-72-8; 3-Bromo-2-Phenylimidazo[1,2-A]Pyrimidine

该化合物是一种混合循环化合物,其组成为一个有三级三联型和二级苯基组的联苯替代的联苯基[1-2]pyrimidine核心.这一结构在合成应用中具有多功能性,特别是作为制药和农用化学研究的关键中间体.溴混合物通过交叉反应为进一步功能化提供了再活动性,从而能够建造复杂的分子结构.其硬性剑剑在药用化学中具有优势,可以设计针对不同治疗区的生物活性分子.该化合物的稳定性和定义明确的再活动特征使它成为有机合成和药物发现的一个有价值的建筑块.

结构式图片

相似化合物

15764-47-3 947613-07-2 478043-89-9

物理性质

MSDS等安全信息

上下游产品

2-苯基-咪唑并[1,2-A]嘧啶 2-Phenylimidazo(1,2-A)Pyrimidine 15764-47-3

合成工艺路线路线简述

  • 15764-47-3 = 904814-72-8
    反应条件:1.1 Reagents: Bromine Solvents: Ethanol; Rt; 5 Min,Rt
    标题:A Facile [hydroxy(Tosyloxy)Iodo]Benzene Mediated Synthesis Of 2-Arylimidazo[1,2-A]Pyrimidines And Their Conversion Into 3-Bromo-2-Arylimidazo[1,2-A]Pyrimidines
    作者:Aggarwal,Ranjana; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2006 卷标:(12) 页码:2690-2695]

    70-11-1 + 109-12-6 = 904814-72-8
    反应条件:1.1 Solvents: Acetone; Rt2.1 Reagents: Iodobenzene Diacetate; 15 Min,Rt
    标题:Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation And Thiocyanation Of Fused N-Heterocycles
    作者:Indukuri,Divakar Reddy; Et Al
    参考文献:Synlett 日期:2019 卷标:30(13) 页码:1573-1579]

    109-12-6 + 98-86-2 = 904814-72-8
    反应条件:1.1 Reagents: [hydroxy(Tosyloxy)Iodo]Benzene Solvents: Acetonitrile; 2 H,Reflux1.2 Solvents: Acetonitrile; 6 H,Reflux1.3 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized,Rt2.1 Reagents: Bromine Solvents: Ethanol; Rt; 5 Min,Rt
    标题:A Facile [hydroxy(Tosyloxy)Iodo]Benzene Mediated Synthesis Of 2-Arylimidazo[1,2-A]Pyrimidines And Their Conversion Into 3-Bromo-2-Arylimidazo[1,2-A]Pyrimidines
    作者:Aggarwal,Ranjana; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2006 卷标:(12) 页码:2690-2695]

    15764-36-0 = 904814-72-8
    反应条件:1.1 Reagents: Iodobenzene Diacetate; 15 Min,Rt
    标题:Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation And Thiocyanation Of Fused N-Heterocycles
    作者:Indukuri,Divakar Reddy; Et Al
    参考文献:Synlett 日期:2019 卷标:30(13) 页码:1573-1579]

    15764-47-3 = 904814-72-8
    反应条件:1.1 Reagents: (Bromooxy)Dimethylsulfonium Solvents: Dimethyl Sulfoxide; Rt; 20 H,Rt
    标题:Generation Of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools For C-H Halogenation
    作者:Dalai,Pallaba Ganjan; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2022 卷标:364(5) 页码:1031-1038]

    70-11-1 + 109-12-6 = 904814-72-8
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Solvents: Ethyl Acetate; 3 H,90 °C
    标题:Chemodivergent Synthesis Of N-(Pyridin-2-Yl)Amides And 3-Bromoimidazo[1,2-A]Pyridines From α-Bromoketones And 2-Aminopyridines
    作者:Liu,Yanpeng; Et Al
    参考文献:Rsc Advances 日期:2019 卷标:9(59) 页码:34671-34676]

    109-12-6 + 7257-94-5 = 904814-72-8
    反应条件:1.1 Solvents: Acetonitrile; 6 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized,Rt2.1 Reagents: Bromine Solvents: Ethanol; Rt; 5 Min,Rt
    标题:A Facile [hydroxy(Tosyloxy)Iodo]Benzene Mediated Synthesis Of 2-Arylimidazo[1,2-A]Pyrimidines And Their Conversion Into 3-Bromo-2-Arylimidazo[1,2-A]Pyrimidines
    作者:Aggarwal,Ranjana; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2006 卷标:(12) 页码:2690-2695]

    27126-76-7 + 98-86-2 = 904814-72-8
    反应条件:1.1 Solvents: Acetonitrile; 3 H,Reflux2.1 Solvents: Acetonitrile; 6 H,Reflux2.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized,Rt3.1 Reagents: Bromine Solvents: Ethanol; Rt; 5 Min,Rt
    标题:A Facile [hydroxy(Tosyloxy)Iodo]Benzene Mediated Synthesis Of 2-Arylimidazo[1,2-A]Pyrimidines And Their Conversion Into 3-Bromo-2-Arylimidazo[1,2-A]Pyrimidines
    作者:Aggarwal,Ranjana; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2006 卷标:(12) 页码:2690-2695
📜1-Phenyl-2-(P-Tolylsulfonyloxy)Ethanone置于溴体系中,用 乙醇,乙腈 作为反应溶剂,化学反应 6.0H,反应生成 3-溴-2-苯基-咪唑并[1,2-A]嘧啶
参考文献:Aggarwal,Ranjana; Sumran,Garima,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2006,Vol. 45,# 12,P. 2690-2695
标题:Aggarwal,Ranjana; Sumran,Garima,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2006,Vol. 45,# 12,P. 2690-2695

海关参考信息

专利信息


专利号:US-3855238-A
优先权日:1970-10-14
标 题:Process for preparing n-tertiary-butoxycarbonyl amino acids
发明人：BATESKY D; SCHULTZ W
权利人:EASTMAN KODAK CO
摘要:Amino acids are converted to their N-tertiary-butoxycarbonyl derivatives, which are especially useful for synthesis of polypeptides, by reacting a base addition salt of the amino acid with O-tertiary-butyl S-phenyl thiocarbonate.

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合成参考文献


参考文献:10.1007/s13738-024-03084-w
摘要:Iranfar S, Shiri M, Majedi S, Madankan A, Hooshmand SE, Alizadeh GB, Al-Harrasi A. A time-controlled selective bromination and formylation of 2-arylimidazo[1,2-a]pyridines. J IRAN CHEM SOC. 2024 Aug 19;21(9):2469–75. doi: 10.1007/s13738-024-03084-w.
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