CAS: 83623-93-2; (2S,4S)-1-(Tert-Butoxycarbonyl)-4-Methoxypyrrolidine-2-Carboxylic Acid
该化合物是一个化学化合物,其特点是有五人组成的环状结构,即五人环状环状矿.该化合物有两种虫状酸,有助于其酸性和再活性,以及一种增强溶解性和氢联结潜力的甲氧基组.一种异丁基酯组的存在,具有阻塞性,影响其再活性和稳定性.据(2S,4S)指出,该化合物确定了其分组的空间安排,可能影响其生物活动和相互作用.一般而言,这种化合物可能因其功能组和结构特征而对药物应用或有机合成的中间体感兴趣.
- 英文名称(2S,4S)-1-(Tert-Butoxycarbonyl)-4-Methoxypyrrolidine-2-Carboxylic Acid
- 中文名称(2S,4S)-1-(叔丁氧基羰基)-4-甲氧基吡咯烷-2-羧酸
- IUPAC名称(2S,4S)-1-(tert-butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid
- 其它别名(2S,4S)-1-[(叔-丁氧基)羰基]-4-甲氧基吡咯烷-2-羧酸; (2S,4S)-1-Tert-Butoxycarbonyl-4-Methoxypyrrolidine-2-Carboxylic Acid
- CAS编号83623-93-2
- MFCD编号:MFCD11501217
- EINECS号:862-506-5
- 分子式:C11H19NO5分子量:245.27
- 产品CID: 1824674
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
83624-01-5 200184-87-8 13726-69-7物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号87691-27-8 N-B°C-顺式-4-羟基-L-脯氨酸 | CAS号74-88-4 碘甲烷 | CAS号215918-38-0 (2S,4S)-1-叔丁基 2... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号847978-73-8 1-(tert-butyl) ... | CAS号847978-71-6 1-(tert-butyl) ... | CAS号37813-30-2 B°C-L-羟脯氨酸乙酯 | CAS号51-35-4 L-羟脯氨酸合成工艺路线路线简述
- 847978-73-8 = 83623-93-2
反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 16 H,Rt
标题:The Impact Of Pyrrolidine Hydroxylation On The Conformation Of Proline-Containing Peptides
作者:Taylor,Carol M.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(4) 页码:1306-1315]
37813-30-2 = 83623-93-2
反应条件:1.1 Reagents: 4-Nitrobenzoic Acid,Triphenylphosphine Solvents: Tetrahydrofuran; Rt -> 0 °C1.2 Reagents: Diisopropyl Azodicarboxylate; 0 °C; 90 Min,0 °C1.3 Reagents: Sodium Azide Solvents: Methanol; 18 H,40 °C2.1 Reagents: Sodium Hydride,18-Crown-6 Solvents: Tetrahydrofuran; 30 Min,Rt; 18 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Rt3.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 16 H,Rt
标题:The Impact Of Pyrrolidine Hydroxylation On The Conformation Of Proline-Containing Peptides
作者:Taylor,Carol M.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(4) 页码:1306-1315]
= 83623-93-2
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 14 H,Rt
标题:The Aberrance Of The 4S Diastereomer Of 4-Hydroxyproline
作者:Shoulders,Matthew D.; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(31) 页码:10857-10865]
132622-90-3 = 83623-93-2
反应条件:1.1 Reagents: Silver Oxide (Ag2O) Solvents: Acetone; 48 H,Rt2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 14 H,Rt
标题:The Aberrance Of The 4S Diastereomer Of 4-Hydroxyproline
作者:Shoulders,Matthew D.; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(31) 页码:10857-10865]
440678-63-7 = 83623-93-2
反应条件:1.1 Reagents: Sodium Hydride,18-Crown-6 Solvents: Tetrahydrofuran; 30 Min,Rt; 18 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 16 H,Rt
标题:The Impact Of Pyrrolidine Hydroxylation On The Conformation Of Proline-Containing Peptides
作者:Taylor,Carol M.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(4) 页码:1306-1315]
24424-99-5 + 51-35-4 = 83623-93-2
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 0 °C; 0 °C -> Rt; 16 H,Reflux1.2 Reagents: Triethylamine Solvents: Dichloromethane; 17 H,Rt2.1 Reagents: 4-Nitrobenzoic Acid,Triphenylphosphine Solvents: Tetrahydrofuran; Rt -> 0 °C2.2 Reagents: Diisopropyl Azodicarboxylate; 0 °C; 90 Min,0 °C2.3 Reagents: Sodium Azide Solvents: Methanol; 18 H,40 °C3.1 Reagents: Sodium Hydride,18-Crown-6 Solvents: Tetrahydrofuran; 30 Min,Rt; 18 H,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Rt4.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 16 H,Rt
标题:The Impact Of Pyrrolidine Hydroxylation On The Conformation Of Proline-Containing Peptides
作者:Taylor,Carol M.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(4) 页码:1306-1315
📜N-Boc-顺式-4-羟基-L-脯氨酸甲酯置于水,Sodium Hydride,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,Mineral Oil 作为反应溶剂,化学反应 12.5H,反应生成 顺式-1-N-Boc-4-甲氧基-L-脯氨酸
参考文献:Hepatitis C Virus Inhibitors And Uses Thereof In Preparation Of Drugs
标题:Hepatitis C Virus Inhibitors And Uses Thereof In Preparation Of Drugs
摘要:一系列丙型肝炎病毒(hcv)抑制剂及其组合物,以及在制备用于治疗慢性hcv感染的药物时的应用.特别是一系列用作ns5A抑制剂的化合物,以及在药物制剂中的组合物和用途.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399002-1,4-丁二醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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合成参考文献
参考文献:10.1021/ja103082y
摘要:Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The aberrance of the 4S diastereomer of 4-hydroxyproline. J Am Chem Soc. 2010 Aug 11;132(31):10857–65.
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