CAS: 82205-58-1; 1-(5-Nitropyridin-2-yl)Piperazine

该化合物是化学化合物,其特点是用5-亚硝基甲虫胺替换的管子子核心,该化合物通常具有分子结构,其中包括一个含有两个氮原子的六人饱和异环,由六人组成的管子环,这是一个含有两个氮原子的饱和异体循环.硝基丙烯基苯组的存在既含有硝基化合物组的电吸附特性,也含有由于环氮原子的氢联结潜力.该化合物经常因其生物活动,特别是在药用化学领域,而受到研究.该化合物可能具有与药理学有关的特性,例如作为各种受体或酶的离子体,其溶性和稳定性取决于溶剂和条件,因此在实验应用中必须考虑到这些因素.此外,由于硝基组的存在,应当注意安全和处理预防措施,因为该组的存在可能与毒性和环境关切有关.

结构式图片

相似化合物

193902-78-2 55403-34-4 1185319-62-3

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号193902-78-2 1-B°C-4-(5-硝基-2... | CAS号110-85-0 哌嗪 | CAS号4487-59-6 2-溴-5-硝基吡啶 | CAS号1227862-56-7 1-(5-nitropyrid... | CAS号4548-45-2 2-氯-5-硝基吡啶 | CAS号193902-78-2 1-B°C-4-(5-硝基-2... | CAS号119285-07-3 4-(5-氨基吡啶-2-基)哌... | CAS号119285-06-2 3-Pyridinamine,... | CAS号92808-20-3 6-(4-乙酰基哌嗪-1-基)...

合成工艺路线路线简述

  • 4487-59-6 + 57260-71-6 = 82205-58-1
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Water; Rt -> 150 °C; 15 Min,150 °C2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 2 H,Rt
    标题:Synthesis And Solid State Study Of Pyridine- And Pyrimidine-Based Fragment Libraries
    作者:Spencer,John; Et Al
    参考文献:Tetrahedron Letters 日期:2011 卷标:52(45) 页码:5905-5909]

    193902-78-2 = 82205-58-1
    反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane
    标题:Lead Optimization Of A Pyridine-Carboxamide Series As Dgat-1 Inhibitors
    作者:Ting,Pauline C.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(4) 页码:985-988]

    4548-45-2 + 57260-71-6 = 82205-58-1
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dimethylformamide; 100 °C2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane
    标题:Lead Optimization Of A Pyridine-Carboxamide Series As Dgat-1 Inhibitors
    作者:Ting,Pauline C.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(4) 页码:985-988]

    4548-45-2 = 82205-58-1
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol,Acetonitrile; Rt
    标题:Design And Synthesis Of Pyridine-Substituted Itraconazole Analogues With Improved Antifungal Activities,Water Solubility And Bioavailability
    作者:Liu,Yu; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(16) 页码:4779-4783]

    4548-45-2 = 82205-58-1
    反应条件:1.1 Solvents: Acetonitrile; 2.5 H,Rt
    标题:Syntheses And Antibacterial Activity Of A Series Of 3-(Pyridine-3-Yl)-2-Oxazolidinone
    作者:Cui,Yingjie; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2005 卷标:40(2) 页码:209-214]

    4487-59-6 = 82205-58-1
    反应条件:1.1 Solvents: Acetonitrile; 18 H,Reflux
    标题:Identification And Biological Evaluation Of 4-(3-Trifluoromethylpyridin-2-Yl)Piperazine-1-Carboxylic Acid (5-Trifluoromethylpyridin-2-Yl)Amide,A High Affinity Trpv1 (Vr1) Vanilloid Receptor Antagonist
    作者:Swanson,Devin M.; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2005 卷标:48(6) 页码:1857-1872
📜2-溴-5-硝基吡啶置于potassium Carbonate,三氟乙酸体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 2.25H,反应生成 1-(5-硝基吡啶-2-基)哌嗪
参考文献:Synthesis And Solid State Study Of Pyridine-And Pyrimidine-Based Fragment Libraries
标题:Synthesis And Solid State Study Of Pyridine-And Pyrimidine-Based Fragment Libraries
摘要:A Library Of Pyridines And Pyrimidines Has Been Synthesised In Excellent Yields Employing Microwave And Flow Chemistry Methodologies. Work-Up Bottlenecks Have Been Facilitated Substantially By The Use Of Supported Reagents And Many Of The Final Compounds Have Been Studied In The Solid State By Single Crystal X-Ray Diffraction. Crown Copyright (C) 2011 Published By Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2011.07.147

海关参考信息

专利信息


专利号:RU-2152940-C1
优先权日:1994-07-12
标 题:Heterocyclic derivatives of azolones effecting against helicobacter, pharmaceutical composition and method of their synthesis

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合成参考文献


参考文献:10.1016/j.bmcl.2007.01.110
摘要:Yoshida T, Sakashita H, Akahoshi F, Hayashi Y. [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors. Bioorg Med Chem Lett. 2007 May 01;17(9):2618–21. doi: 10.1016/j.bmcl.2007.01.110.
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