CAS: 821-48-7; Bis(2-Chloroethyl)Amine Hydrochloride

相似化合物

334-22-5 10429-82-0 118753-70-1

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CAS号111-42-2 二乙醇胺 | CAS号38212-33-8 1-(4-氯苯基)哌嗪 | CAS号4004-95-9 1-苯基哌嗪双盐酸盐 | CAS号39512-51-1 1-(2-甲基苯基)哌嗪 | CAS号39800-29-8 O-(3-丁烯基)-N,N-双... | CAS号38869-47-5 1-(4-甲氧基苯基)哌嗪盐酸盐 | CAS号55-51-6 N,N-双(2-氯乙基)苯甲胺 | CAS号38212-30-5 1-(4-甲氧基苯基)哌嗪 | CAS号55-86-7 盐酸氮芥 | CAS号144881-51-6 1-(4-propan-2-y... | CAS号50-18-0 环磷酰胺

N,N,N',N'-Tetrakis(2-Chloroethyl)Methanediamine置于乙酰氯体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 二(2-氯乙基)胺盐酸盐
参考文献:曼尼希碱的烷基化和嵌入性能对细胞毒活性的评价
标题:曼尼希碱的烷基化和嵌入性能对细胞毒活性的评价
摘要:设计并合成了一系列新的"杂化化合物",即平面多环/杂环起始原料的曼尼希碱衍生物.化合物的结构通过光谱法和元素分析确认.在三种癌细胞系(pc3,Hela和mcf7)和一种非肿瘤细胞系(293 Hek)中研究了化合物的细胞毒性.我们通过溴化乙锭(etbr)荧光置换实验测试了分子的dna嵌入能力.通过使用2-巯基乙醇(一种仿生亲核试剂)的体外孵育测试,研究了化合物的烷基化能力.文献中首次报道了这五个化合物(7S,9D,10B,11B,12C).我们的结果表明,化合物9D的生物学活性接近于参考化合物阿霉素,
DOI:10.2174/1570180811666140529005029

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-9493409-B2
优先权日:2013-04-04
标题 :Process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides new intermediate compounds or formulae (III) and (IVa), and salts thereof, and their use in a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine) an experimental drug under development for the treatment of depression and anxiety.

专利号:US-2005095280-A1
优先权日:2003-10-15
标 题:Single-component pH-sensitive liposomes of reduced solid-to-liquid phase transition temperatures
发明人：SAVVA MICHALAKIS
权利人:MICHALAKIS SAVVA
摘要:The current invention relates to the synthesis of novel cationic lipids and their use as delivery vectors for nucleic acids, peptides and other synthetic drugs, in vitro and in vivo. The cationic lipids described herein form stable lamellar structures (liposomes) at physiological pH but destabilize to micelles at acidic and alkaline pH. These structures are characterized of high elasticity, increased fluidity and high transfection activity relative to the corresponding 1,2-dialkyl cationic derivatives and other phospholipids analogues.

专利号:US-9944579-B2
优先权日:2015-01-15
标题 :Catalytic hydrogenation process for the synthesis of terminal diols from terminal dialkyl aliphatic esters
发明人：BALARAMAN EKAMBARAM; SAHOO MANOJ KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:A phosphorus ligand-free, mild, efficient and complete catalytic hydrogenation process is for the sustainable production of terminal diols from renewable terminal dialkyl esters with improved yield. Soluble, phosphorus ligand free Ru (II)-pincer type complexes can be used as catalysts in the hydrogenation process.

专利号:US-2021402380-A1
优先权日:2020-06-23
标 题 :Perovskites for photocatalytic organic synthesis
发明人：YAN YONG
权利人:SAN DIEGO STATE UNIV FOUNDATION
摘要:Nature is capable of storing solar energy in chemical bonds via photosynthesis through a series of C—C, C—O and C—N bond-forming reactions starting from CO 2 and light. Direct capture of solar energy for organic synthesis is a promising approach. Lead (Pb)-halide perovskite solar cells reach 24.2% power conversion efficiency, rendering perovskite a unique type material for solar energy capture. We show that photophysical properties of perovskites is useful in photoredox organic synthesis. Because the key aspects of these two applications are both relying on charge separation and transfer. Here we demonstrated that perovskites nanocrystals are exceptional candidates as photocatalysts for fundamental organic reactions, i.e. C—C, C—N and C—O bond-formations. Stability of CsPbBr 3 in organic solvents and ease-of-tuning their bandedges garner perovskite a wider scope of organic substrate activations.

专利号:US-2003236435-A1
优先权日:2002-05-15
标题 :Synthesis of 2-alkylcysteine via substituted thiazoline ester