CAS: 76041-74-2; 3-Chloro-5-(Trifluoromethyl)Pyridine-2-Thiol

该化合物是一种杂交循环化合物,其特点是存在一种由氯原子和三氟甲基组组成的环状,以及一个硫醇功能组.分子结构具有一种环状环状环状,这是一个六人组成的芳香环,含有一个氮原子,有助于其基本性和再活动.三氟甲基组群增强了化合物的亲性,并能够影响其电子特性,使其在各种化学应用中具有潜在用途.硫醇(SH)组具有核分裂生物特性,允许参与各种化学反应,包括分解联结形成和金属协调.该化合物可能展示生物活动,使其对制药研究感兴趣.它独特的功能组群组合表明其在农业化学,材料科学以及作为有机合成的建筑块中的潜在应用.由于氯和氟化物的存在,应观测到安全和处理预防措施,因为氯和氟素的存在可能构成健康和环境风险.

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CAS号69045-84-7 2,3-二氯-5-三氟甲基吡啶 | CAS号69045-83-6 2,3-二氯-5-三氯甲基吡啶

合成工艺路线路线简述

    📜2,3-二氯-5-三氟甲基吡啶置于氢氧化钾,水,硫脲体系中,化学反应生成 3-氯-5-三氟甲基吡啶-2-硫醇
    参考文献:Haga,Takahiro; Fujikawa,Kan-Ichi; Koyanagi,Tohru,Heterocycles,1984,Vol. 22,# 1,P. 117-124
    标题:Haga,Takahiro; Fujikawa,Kan-Ichi; Koyanagi,Tohru,Heterocycles,1984,Vol. 22,# 1,P. 117-124

    海关参考信息

    专利信息


    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

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