CAS: 70067-45-7; 4-Isocyanatopyridine

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4-氨基吡啶 4-Aminopyridine 504-24-5

📜异烟酸置于叠氮磷酸二苯酯,三乙胺体系中,用 甲苯 作为反应溶剂,化学反应 2.5H,反应生成 4-异氰酸酯吡啶
参考文献:Oxindole Derivatives
标题:Oxindole Derivatives
摘要:这项发明描述了一般式i的化合物或其药用盐,其中r1,R2,R3和x在此处描述,以及它们的制备方法,含有它们的药物以及将这些化合物用作药用活性剂的用途.这些化合物显示出抗增殖剂的活性,可能特别适用于癌症的治疗.

专利信息

专利号:US-4366317-A
优先权日:1981-06-22
标题 :Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3-carboxamide
发明人：HAUT STEPHEN A; COMES ROGER A
权利人:PHILIP MORRIS INC
摘要:This invention provides an improved process for synthesizing carboxamides which involves reacting 3-p-menthyl halide with magnesium to form 3-p-menthylmagnesium halide Grignard reagent, and reacting the Grignard reagent with hydrocarbyl isocyanate at a temperature below about -20 DEG C. to form N-hydrocarbyl-p-menthane-3-carboxamide product. The product comprises a mixture of geometric isomers in which the 3-p-menthyl:3-p-neomenthyl weight ratio is at least 4:1 and can be as high as 9:1 under optimal conditions. This invention also provides a novel process for producing acylurea compounds such as N-(3-p-menthylcarbonyl)-N-t-butyl-N'-t-butylurea.