专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
专利号:US-7495108-B2 优先权日:2004-02-19 标 题:Imidazoline derivatives having CB1-antagonistic activity 发明人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN STUIVENBERG HERMAN H 权利人:SOLVAY PHARM BV 摘要:The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these imidazoline derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) n nwherein the symbols have the meanings given in the specification.
专利号:US-7498348-B2 优先权日:2003-10-20 标题 :1 H-imidazole derivatives as cannabinoid receptor modulators 发明人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN STUIVENBERG HERMAN H; KEIZER HISKIAS G 权利人:SOLVAY PHARM BV 摘要:The invention relates to a group of 1H-imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders in which cannabinoid receptors are involved. n The compounds have the general formula (I) n nwherein R, R 1 -R 4 and X have the meanings given in the specification.
专利号:US-8461184-B2 优先权日:2006-05-31 标题 :Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists 发明人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J 权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VLIET VAN BERNARD J; SOLVAY PHARM BV 摘要:The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB 1 receptor antagonists having a high CB 1 /CB 2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of these pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) n nwherein the symbols have the meanings given in the specification.
专利号:WO-2007138050-A1 优先权日:2006-05-31 标题:Sulphur containing pyrazole derivatives as selective cannabinoid cb1 receptor antagonists 发明人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN VLIET BERNARD J 权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN VLIET BERNARD J 摘要:The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB1 receptor antagonists having a high CB1/CB2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
专利号:EP-1675833-B1 优先权日:2003-10-20 标 题 :1h-imidazole derivatives as cannabinoid receptor modulators 发明人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; VAN STUIVENBERG HERMAN H; KEIZER HISKIAS G 权利人:ABBOTT HEALTHCARE PRODUCTS BV 摘要:The invention relates to a group of 1H -imidazole derivatives which are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders in which cannabinoid receptors are involved. The compounds have the general formula (I) wherein R, R1-R4 and X have the meanings given in the specification.
参考文献:10.1556/abiol.60.2009.4.5 摘要:Nadia BH, Wided K, Kheira B, Hassiba R, Lamia B, Rhouati S, Alyane M, Zellagui A, Lahouel M. Disruption of mitochondrial membrane potential by ferulenol and restoration by propolis extract: antiapoptotic role of propolis. Acta Biol Hung. 2009 Dec;60(4):385–98. doi: 10.1556/abiol.60.2009.4.5. 摘要:Williams, A. C.; Camp, N., Science of Synthesis, (2003) 14, 450.